Table 5 Urease inhibitory screening results of the synthesized compounds (T1T20)

From: Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents

Compounds % inhibition IC50 (µg/ml)
25 (µg/ml) 50 (µg/ml) 75 (µg/ml) 100 (µg/ml)
T1 25.76 47.98 72.9 91.99 51.70
T2 40.45 49.54 55.67 67.57 53.04
T3 28.19 50.00 65.89 79.12 54.01
T4 35.45 49.45 63.67 79.45 50.52
T5 23.34 44.35 70.87 90.87 54.46
T6 38.45 50.34 65.61 80.89 47.02
T7 23.98 46.89 76.09 91.90 52.07
T8 22.45 39.58 68.58 92.67 56.43
T9 33.45 53.67 70.46 92.67 46.34
T10 27.90 46.89 70.90 89.80 51.90
T11 25.00 42.45 68.88 92.67 54.59
T12 43.56 46.57 52.56 61.56 58.06
T13 26.57 48.78 73.98 98.89 50.05
T14 41.70 46.23 50.49 57.78 67.02
T15 29.03 37.14 61.78 73.12 61.04
T16 45.76 49.10 53.87 59.12 52.85
T17 37.91 42.38 57.61 71.42 57.47
T18 40.90 46.79 55.89 67.9 54.30
T19 31.89 47.98 52.98 65.87 63.24
T20 28.98 49.09 69.09 81.90 52.34
Thiourea 29.98 46.76 67.78 76.78 54.25
  1. Italics signifies the most active compound in comparison to the standard compound