Table 1 Physicochemical characterization of synthesized derivatives (T1T20)

From: Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents

Comp Mol. formula Mol. wt Colour M.p. (°C) Rf value % Yield
Int-ii C18H36O 284.84 White 121–124 0.37a 71.0
Int-iii C17H31N2OS 312.51 Yellow 154–157 0.42a 52.1
Int-iv C17H34N4S 326.54 Pinkish white 178–181 0.41b 46.0
T1 C24H38N4S 414.65 Creamish white 184–187 0.40b 78.0
T2 C25H38N4OS 442.66 Light brown 182–185 0.33b 82.0
T3 C25H40N4S 428.68 Yellowish white 190–193 0.52b 74.0
T4 C26H43N4O2S 474.70 White 188–191 0.60b 85.0
T5 C27H44N4O3S 504.73 Yellow 187–190 0.38b 79.5
T6 C25H40N4O2S 460.68 Creamish white 189–192 0.49b 84.6
T7 C24H38N4OS 430.65 Lemon yellow 181–184 0.32b 78.0
T8 C24H38N4OS 430.65 Greenish white 192–195 0.73b 65.9
T9 C26H43N5S 457.72 Green 198–201 0.62b 75.0
T10 C24H37ClN4S 449.10 Pinkish white 205–208 0.59b 79.6
T11 C24H37ClN4S 449.10 White 202–205 0.65b 78.0
T12 C24H36Cl2N4S 483.54 White 211–214 0.34b 74.3
T13 C24H37BrN4S 493.55 White 197–200 0.39b 89.2
T14 C24H37BrN4S 493.55 Brownish yellow 193–196 0.71b 85.8
T15 C24H37N5O2S 459.65 Mustard yellow 195–198 0.68b 78.9
T16 C24H37N5O2S 459.65 Dark yellow 199–202 0.45b 90.0
T17 C24H37N5O2S 459.65 Brown 206–209 0.50b 85.8
T18 C28H40N4OS 480.71 Red 186–189 0.67b 88.8
T19 C26H40N4OS 440.69 Creamish white 179–182 0.24b 87.9
T20 C22H36N4OS 404.61 White 196–199 0.43b 87.0
  1. Mobile phase: a[chloroform:toluene, 7:3], b[ethylacetate:n-hexane, 2:3]