Antimicrobial, antioxidant and cytotoxic evaluation of diazenyl chalcones along with insights to mechanism of interaction by molecular docking studies

Table 2 MBC/MFC (µg ml⁻¹) of diazenyl chalcones (C18–C27) against various microbial strains

Compound	B. cereus MBC (µg ml⁻¹)	S. typhi MBC (µg ml⁻¹)	E. coli MBC (µg ml⁻¹)	S. aureus MBC (µg ml⁻¹)	B. subtilis MBC (µg ml⁻¹)	C. albicans MFC (µg ml⁻¹)	A. fumigatus MFC (µg ml⁻¹)
C-18	125	125	62.5	125	125	125	125
C-19	500	125	500	125	62.5	125	250
C-20	125	125	250	125	125	250	125
C-21	62.5	125	31.25	125	62.5	125	125
C-22	3.90	7.81	7.81	31.25	7.81	31.25	125
C-23	62.5	62.5	15.62	125	62.5	125	125
C-24	15.62	15.62	31.25	15.62	62.5	125	125
C-25	125	125	125	62.5	62.5	62.5	62.5
C-26	250	62.5	125	31.25	62.5	125	125
C-27	125	62.5	15.62	62.5	31.25	62.5	125
Dye A	31.25	62.5	31.25	125	125	62.5	125
Dye E	62.5	125	31.25	62.5	125	125	125
Chalcone	62.5	62.5	31.25	62.5	62.5	125	125
Cefadroxil	31.25	125	31.25	31.25	125	–	–
Cefotaxime	15.62	7.81	7.81	31.25	7.81	–	–
SXT	7.81	3.90	1.95	7.81	15.62	–	–
CIP	15.62	7.81	7.81	3.90	15.62	–	–
Fluconazole	–	–	–	–	–	31.25	125

Chalcone (E)-3-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, SXT Sulfamethoxazole/trimethoprim; CIP ciprofloxacin