Decreased outlet angle of the superior cerebellar artery as indicator for dolichoectasia in late onset Pompe disease
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Abstract
Background
Lysosomal α-glucosidase deficiency (Pompe disease) not only leads to glycogen accumulation in skeletal muscle, but also in the cerebral arteries. Dolichoectasia of the basilar artery (BA) has been frequently reported. Therefore progression of BA dolichoectasia in late onset Pompe patients (LOPD) was studied.
Methods
BA length, diameter and volume, and cerebral lesions were analysed by MRI/TOF-MR angiography or CT/CT angiography in 20 LOPD patients and 40 controls matching in age, sex- and cardiovascular risk factors. The height of BA bifurcation was assessed semi-quantitatively using the Smoker’s criteria and quantitatively by measuring the outlet angle of the superior cerebellar artery (SUCA). Nine patients were followed over 5 years.
Results
The height of the BA bifurcation was abnormal in 12/20 (60%) LOPD patients and in 12/40 (30%) matched controls. The SUCA outlet angle was reduced in LOPD patients compared to controls (127 ± 33° vs. 156 ± 32°, p = 0.0024). The diameter, length and volume of the BA were significantly increased in LOPD patients compared to controls. 12/20 (60%) LOPD patients and 27/40 (68%) controls presented white matter lesions. During 5 years 2/9 LOPD patients developed an abnormal height of BA bifurcation according to the Smoker’s criteria and in all patients the SUCA outlet angle decreased (138 ± 34° vs. 128 ± 32°, p = 0.019). One patient with prominent basilar dolichoectasia experienced a thalamic hemorrhage.
Conclusion
Pompe disease is associated with BA dilation, elongation and elevated bifurcation height of the BA which might result in cerebrovascular complications. The SUCA outlet angle seems to be useful for monitoring the progression of BA dolichoectasia.
Keywords
Late onset Pompe disease (LOPD) Dolichoectasia of basilar artery Dilative arteriopathy Height of basilar bifurcation Glycogenosis type II Superior cerebellar artery (SUCA SCA) Acid maltase deficiencyAbbreviations
- BA
Basilar artery
- ERT
Enzyme replacement therapy
- LOPD
Late onset Pompe disease
- SUCA
Superior cerebellar artery
- VA
Vertebral artery
Background
Pompe disease (glycogenosis type II, OMIM# 232300) is a multi-systemic disorder caused by reduced activity of the lysosomal acid glycosidase α presenting with predominant muscular weakness, respiratory and cardiac insufficiency [1]. Autopsy studies showed glycogen accumulation also in smooth muscles of the tunica media of cerebral arteries indicating involvement of the cerebrovascular system [2]. Microangiopathies (e.g. white matter lesions, microbleeds) and macroangiopathies (e.g. dolichoectasia and aneurysms mostly of vertebrobasilar arteries) have been repeatedly reported in late onset Pompe disease (LOPD) [3]. Cerebrovascular complications might be crucial for long term survival of LOPD patients as these cerebrovascular changes were associated with intracranial haemorrhages, compression of cranial nerves and brainstem, and stroke [3, 4, 5, 6]. Recent studies have demonstrated that dolichoectasia of the basilar artery (BA) is the most striking cerebrovascular finding in LOPD patients [3]. A preliminary study showed a significant dilation of vertebrobasilar arteries compared to controls [7]. However, little is known about the progression of this arterial remodelling in the course of LOPD. Therefore this study investigated how BA characteristics of 20 LOPD patients differ from those of 40 subjects that individually matched the LOPD patients in age-, sex-, and risk factors. Secondly the progression of BA arteriopathy during a 5 year observation period was analysed retrospectively for 9 of the 20 LOPD patients. Finally the occurrence of cerebral lesions was examined.
Patients and controls
Clinical and molecular data of 20 LOPD patients
Pat.-Nr. | Sex | GAA-Genotype | Age [years] | Duration disease (years) | Duration ERT (month) | Cardio-vascular risk factors | |
---|---|---|---|---|---|---|---|
P1a | F | IVS1 (− 13 T > G) | IVS9 G > C) | 26 | 15 | 67 | HL |
P2 | F | p.L552P | p.P493L | 37 | 10 | 33 | HL, O |
P3a | M | IVS1 (−13 T > G) | c.2136-7delGT | 50 | 40 | 116 | HYP, HL |
P4a | M | IVS1 (−13 T > G) | p.W499R | 50 | 18 | 130 | DM, HL |
P5a | M | IVS1 (−13 T > G) | p.P493L | 52 | 15 | 63 | HYP, HL |
P6a | F | IVS1 (−13 T > G) | p.L552P | 53 | 17 | 99 | HYP, HL, O, S |
P7a | M | IVS1 (−13 T > G) | p.C103G | 59 | 14 | 135 | HYP, DM, HL, O |
P8a | F | IVS1 (−13 T > G) | p.P493L | 61 | 21 | 63 | HYP, HL |
P9 | M | IVS1 (−13 T > G) | p.G309R | 64 | 11 | 14 | HYP, DM, O |
P10a | F | IVS1 (−13 T > G) | del exon 18 | 75 | 40 | 103 | HYP |
P11 | M | IVS1 (−13 T > G) | c.832delC | 45 | 6 | 17 | HYP, HL |
P12 | F | IVS1 (−13 T > G) | c.525delT | 66 | 7 | 33 | HYP, HL |
P13 | M | IVS1 (−13 T > G) | IVS1 (−13 T > G) | 61 | 13 | 29 | HYP, HL |
P14 | F | IVS1 (−13 T > G) | c.2481 + 102_2646 + 31del | 54 | 18 | 44 | HYP, HL |
P15 | F | IVS1 (−13 T > G) | c.2481 + 102_2646 + 31del | 56 | 19 | 48 | HYP, HL |
P16a | F | IVS1 (−13 T > G) | c307 T > G | 49 | 23 | 119 | HL |
P17 | M | IVS1 (−13 T > G) | p.G309R | 81 | 6 | 37 | HYP, HL |
P18 | M | IVS1 (−13 T > G) | c.794delG | 49 | 13 | 84 | NONE |
P19 | F | IVS1 (−13 T > G) | c.925G > A | 61 | 2 | 9 | HYP |
P20 | M | IVS1 (−13 T > G) | c.525delT | 19 | 19 | 132 | NONE |
For each Pompe patient two controls (n = 40; age 54.0 ± 14.7 years, range 19 to 80) were recruited that matched in gender, age (maximal ±3 years) and number of cerebrovascular risk factors (maximal ±1). Relevant risk factors were defined as hypertension, hyperlipidemia, obesity, smoking and diabetes. The control group consisted of patients with other neurological diseases that underwent cerebral MRI imaging for diagnostic purpose. This included headache (11/40), TIA and minor cardioembolic stroke (7/10), peripheral neuropathies (5/40), seizures (4/40), myopathies other than Pompe disease (3/40), other diagnoses (10/40) were retrobulbar optic neuritis, anterior ischemic optic neuropathy, spinocerebellar syndrome, dementia, and psychiatric diseases.
Methods
Basilar artery (BA) and the outlet angle of the superior cerebellar artery (SUCA) Assessment of the BA length and bifurcation height and SUCA outlet angle. a) A 57 year old male control patient with normal height of the BA bifurcation (grade 0 according to Smoker criteria [8]) and nearly perpendicular SUCA outlet from the basilar artery (angle right: 85°, angle left: 75°; SUCA outlet angle of 160° as defined by sum of left and right side). b) A 61 year old female LOPD patient with dilated basilar artery, cranial shifted BA bifurcation indenting the third ventricle and hypothalamus (*, grade 3 according to Smoker’s criteria [8]) and low SUCA outlet angle (angle right: 48°, angle left: 31°; SUCA outlet angle of 79° as defined by sum of left and right side). Schematic drawings indicate measurements of SUCA outlet angles (red angles) and measurements of basilar artery: anatomic length (line a) and linear length (line b)
Results
BA characteristics in 20 LOPD patients and 40 controls
Characteristics of basilar artery in LOPD and controls measured by TOF-MRA
LOPD (n = 20) | controls (n = 40) | p-value ‡ | |
---|---|---|---|
Basilar artery characteristics | |||
- Diameter (mm) | |||
• proximal • middle • distal | 3.5 ± 0.8 3.2 ± 1.2 3.2 ± 1.1 | 3.1 ± 1.0 2.4 ± 0.4 2.7 ± 0.6 | p = 0.130 p = 0.0006 p = 0.013 |
- Anatomical length (mm) | 34.0 ± 6.6 | 30.7 ± 5.2 | p = 0.039 |
- Linear length (mm) | 31.3 ± 3.7 | 29.1 ± 4.0 | p = 0.051 |
- Volume (ml) | 0.209 ± 0.164 | 0.113 ± 0.547 | p = 0.0014 |
Smoker criteria [8] | |||
- Abnormal lateral BA displacement (≥ grade 2) | 1/20 (5%) | 1/40 (2.5%) | p = 1.00 |
- Abnormal height of BA bifurcation (≥ grade 2) | 12/20 (60%) | 12/40 (30%) | p = 0.049 |
Other parameter | |||
SUCA outlet angle (°) | 127 ± 33a | 156 ± 32 | p = 0.0024 |
White matter lesions | 12/19 (63%)b | 27/40 (68%) | p = 0.77 |
In LOPD patients, there was a positive correlation between BA anatomical length (Pearson r = 0.626, p = 0.0.003), linear length (Pearson r = 0.522, p = 0.018), distal diameter (patients: Pearson r = 0.536, p = 0.015), and volume (Pearson r = 0.516, p = 0.020) with age.
SUCA outlet angle and age in LOPD patients and controls. SUCA outlet angle showed to be age dependent. Assessment of the SUCA outlet angle (in °, sum of left and right) showed to be reduced in higher age in LOPD patients (▲) and matched controls (○). Regression lines for LOPD patients (solid line) and for controls (dashed line) are shown
In total, in the cohort of all subjects (LOPD patients and controls) the SUCA outlet angle correlated with BA anatomic length (Pearson r = − 0,558, p < 0.001), the BA linear length (Pearson r = − 0.546, p < 0.001), the BA volume (Pearson r = − 0,545, p < 0.001). Correlations according to the Smoker criteria were as follows: with BA diameter (distal: Pearson r = − 0.407, p = 0.001; middle: Pearson r = − 0.363, p = 0.005; proximal: Pearson r = − 0.280, p = 0.032), and the grade of the BA bifurcation height (Pearson r = − 0.653, p < 0.001) and with the extend of the lateral displacement (Pearson r = − 0.287, p = 0.028).
There was no gender difference in BA diameter, anatomic length, linear length, volume or SUCA outlet angle in LOPD patients or controls.
BA characteristics during 5 year follow-up in 9 LOPD patients
Characteristics of basilar artery in 9 LOPD patients during 5 year follow up measured by TOF-MRA
Baseline | 5 year follow-upa | p values | |
---|---|---|---|
Basilar artery characteristics | |||
- Diameter (mm) | |||
• proximal • middle • distal | 3.8 ± 1.8 3.2 ± 0.7 2.9 ± 0.8 | 3.6 ± 0.9 3.5 ± 1.5 3.3 ± 1.4 | p = 0.512 p = 0.584 p = 0.143 |
- Anatomic length (mm) | 33.2 ± 7.5 | 33.4 ± 8.2 | p = 0.808 |
- Linear length (mm) | 30.3 ± 2.9 | 30.1 ± 3.9 | p = 0.799 |
- Volume (ml) | 0.214 ± 0.138 | 0.240 ± 0.211 | p = 0.475 |
Smokers criteria | |||
- Abnormal lateral BA displacement | 0/9 (0%) | 0/9 (0%) | p = 1.00 |
- Abnormal height of BA bifurcation | 3/9 (33%) | 5/9 (56%) | p = 0.64 |
Other parameter | |||
SUCA outlet angle (°) | 138 ± 34 | 128 ± 32 | p = 0.019 |
White matter lesionsb | 5/8 (63%) | 5/8 (63%) | p = 1.00 |
Other cerebral abnormalities
During the observation period of 5 years, there were no major cerebrovascular events in 8/9 LOPD patients. However, one of the patients, a 75 year- old female, experienced an intracranial thalamic haemorrhage on the left side that led to complete immobilisation and subsequent death. This patient presented a remarkable dolichoectasia of the BA with an extreme cranial and posteriorly shifting of the BA bifurcation (Additional file 1 Figure S1).
White matter lesions were observed in 12/19 LOPD patients (63%) and 27/40 controls (68%). According to the Fazekas score grading of the LOPD patients was as follows: 40% grade 0, 30% grade 1, 25% grade 2, 5% grade 3. Grading of controls was: 32.5% grade 0, 40% grade 1, 20% grade 2, 7.5% grade 3. On a group level, Fazekas grade was not different in the LOPD patients compared to controls (0.95 ± 0.95 versus 1.05 ± 0.96). In controls, there were no major cerebrovascular abnormalities (e.g. tumor, major stroke, aneurysms).
None of the 9 LOPD patients showed progression of deep white matter lesions in within the 5 year period according to the Fazekas criteria.
The lowest SUCA outlet angle was found in the oldest LOPD patient (P17: 64°), who had a dilated BA and an additional severe mid-basilar stenosis. Other low SUCA outlet angles were found in one patient (P8: 79°) with microbleeds that were exclusively present in the posterior circulation and in one (P14: 83°) with a bilaterally fetal-type circle of Willis.
Discussion
Dolichoectasia in patients and controls
The present study on 20 LOPD patients under enzyme replacement therapy (ERT) showed a significant dilation of the BA (regarding diameter and lengths) compared to matched controls. Similar changes have previously reported in 10 of these 20 patients [7]. However, in the present study a more accurate and objective assessment of the vessel diameter was performed using FWHM, based on the pixel-wise intensity [9]. The findings in our cohort are consistent with those of previous studies that found predominant dolichoectasia in the posterior cerebral circulation in LOPD patients with and without ERT [3, 11]. The reason for these changes remains unclear. It was speculated that glycogen deposition in the smooth muscles of the intima of arterial vessels provokes their dilation [2, 12]. In this study all patients received ERT and its impact on cerebral vessels remains enigmatic. However, there is a report that suggests glycogen clearance in smooth muscle via ERT in the arrector pili muscle [13].
However, vertebrobasilar dolichoectasia is not a specific phenomenon in Pompe disease: In general the posterior circulation has less sympathetic innervation than the anterior circulation leading to a predisposition to deformity, when exposed to increased blood flow and pressure [14]. Subsequently, there is physiological progressive luminal dilation, fragmentation of the internal elastic lamina, and elastin loss in aging individuals, that mainly affect the vertebrobasilar arteries [15, 16, 17]. Besides a higher age, also a male gender and cardiovascular risk factors (hypertension, smoking, obesity, diabetes, or dyslipidemia) have been found to be associated with evolution of dolichoectasia [18]. Therefore LOPD patients were individually matched with controls of equal epidemiological and cardiovascular parameters.
Since signs of dolichoectasia were observed in both groups, the LOPD patients and the matched controls, additional factors for the development of dilative arteriopathy have to be assumed that result from the comorbidities. However, the BA ectasia was more pronounced in the LOPD cohort compared to controls. It is therefore suggested that Pompe disease acts as independent factor for the development of BA dolichoectasia.
Until now, the most validated parameters for BA evaluation are the semi-quantitative Smoker’s criteria [8]: An abnormal height of BA bifurcation implies that the BA bifurcation is cranial shifted to the level of third ventricle floor or higher. Normally, the SUCA originates shortly under the BA bifurcation at the height of the free edge of the tentorium cerebelli [19] and the SUCA outlet angle is nearly 180°. If the SUCA origin and the adjacent basilar bifurcation shift cranial, then the SUCA outlet angle will consequently decrease. The SUCA is most consistent and the angle is easily obtained from coronal CT- or MR angiography images, independently from different imaging protocols. Therefor in this study the outlet angle of the SUCA was introduced as a novel parameter for a quantitative analysis of this cranial shift of BA bifurcation. It was demonstrated that the SUCA outlet angle in LOPD patients was significantly reduced compared to controls together with other indicators of a prominent BA ectasia in these patients. Additionally, there was a significant correlation of the SUCA outlet angle with all parameters of the Smoker’s criteria: BA diameter, bifurcation height and lateral displacement.
Analysis of progression of dolichoectasia in LOPD patients
In the present study, according to the Smoker’s criteria [8], only 3/9 LOPD patients showed an abnormal height of the BA bifurcation at baseline but 5/9 LOPD patients after 5 years follow up. In the 5 year follow up analysis there was a significant decline of the SUCA outlet angle in the cohort of 9 LOPD patients on ERT that suggests a progressive dolichoectasia in these patients. The higher slope of the regressionline of the LOPD cohort compared to controls in the age dependent analysis of the SUCA outlet suggests that these differences result from disease specific mechanism rather from the aging of the patients.
However, other parameters that define BA dolichoectasia (length, diameter, and lateral displacement of the BA) remained nearly unchanged. Similar results were reported in a recent study showing stable vertebrobasilar diameters over a period of up to 10 years in 5 LOPD patients [20]. This might be due to the relatively small diameter and lengths of the BA. Changes of these parameters may need time to evolve and are therefore not easily detectable in the 5 year observation period. However, presumed that all vertebrobasilar arteries are affected by a weakening of the vessel wall, and then the cranial migration of the BA bifurcation might be a result of a summation effect of the elongation of the BA plus the adjacent vertebral arteries. Since vasodilation results in reduced flow velocity, the dilation of cerebral arteries might be underestimated in TOF-based MRA. Limitation of this study might be the use of slight differently TOF-MRI protocols in the follow up cerebral imaging. However, this has no impact on the SUCA outlet angle. It is suggested that the SUCA outlet angle is a sensitive surrogate marker for BA dolichoectasia, which detects the elevation of the height of basilar bifurcation in a more precise and quantitative way than the Smoker’s grading.
Clinical relevance
It is well known that dolichoectasia can lead to brainstem compression, hydrocephalus microbleeds and stroke [18, 21, 22]. There are several reports on strokes [6, 23] and intracranial mirco – and macrohemorrhages [4, 5, 24] in Pompe patients. In the actual LOPD cohort a fatal thalamic hemorrhage occurred in one patient with the most prominent basilar dolichoectasia. It can be speculated, that the vertebrobasilar pathology might at least has contributed to the hemorrhage in this patient. However, in all 9 patients there was no progression of white matter lesions after the follow up of 5 years.
It seems therefore appropriate, that patients without cerebrovascular abnormalities undergo a follow up of MRI analysis after 5 years. In patients with cerebrovascular abnormalities, we recommend the strict treatment of cerebrovascular risk factors (e.g. hypertension) and follow up imaging after 1 to 2 years.
Conclusion
Dilation and elongation of the BA is pronounced in LOPD patients under ERT compared to matched controls. This suggests that LOPD acts as an independent risk factor for basilar dolichoectasia. The study demonstrates a decreasing SUCA outlet angle as surrogate marker for a progressive elevation of the BA bifurcation in the disease course of LOPD during a 5 year observation period. The SUCA outlet angle seems to be useful for detection of progression of vertebrobasilar dolichoectasia.
Notes
Acknowledgements
Tobias Mueller, MD (Department of Neurology, University hospital Martin-Luther-University, Halle/Saale, Germany) for supervision of the dupexsonographic studies; Sabine Koesling, Prof. (Department of Diagnostic Radiology, University hospital Martin-Luther-University, Halle/Saale, Germany) for supervision of the radiological analysis; Titus Heyke (VitalAire GmbH, Leipzig, Germany) for technical support of patient CPAP ventilation during MR examination; Torben Schneider, PhD (Philips Healthcare, UK) edited the manuscript for non-intellectual content.
Statistical analysis
Conducted by Ole Hensel, University hospital Halle, Halle/Saale, Germany.
Funding
No funding.
Availability of data and materials
It is stated that the authors have full access to all data and the right to publish any and all data. Please contact the corresponding author for ata requests.
Authors’ contributions
IS, concept and design, acquisition of data, analysis and interpretation of data. OH, study concept and design, acquisition of data, analysis and interpretation of data. MW, acquisition of data, analysis and interpretation of data. TK, acquisition of data, analysis and interpretation of data. SZ, study supervision, analysis and interpretation of data, critical revision of manuscript for intellectual content. All authors read and approved the final manuscript.
Ethics approval and consent to participate
All participants gave their informed consent to take part in the study. The research protocol was approved by the Ethical Committee of the Medical Faculty of the Martin-Luther-University Halle-Wittenberg.
Consent for publication
All participants gave their informed consent to data publication. All authors have read the manuscript and agreed the submission an publication in the OJRD.
Competing interests
Ole Hensel – Reports no disclosures; Ilka Schneider – Honoraria for lectures, travel expenses from Genzyme Corporation; Mathias Wieprecht – Reports no disclosures; Torsten Kraya - Honoraria for lectures, travel expenses from Genzyme Corporation; Stephan Zierz - Honoraria for lectures, travel expenses from Genzyme Corporation.
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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary material
References
- 1.Schneider I, Zierz S. Profile of alglucosidase alfa in the treatment of Pompe disease: safety, efficacy, and patient acceptability. Research and Reports in Endocrine Disorders. 2015;6:1–9.Google Scholar
- 2.Kretzschmar HA, Wagner H, Hubner G, Danek A, Witt TN, Mehraein P. Aneurysms and vacuolar degeneration of cerebral arteries in late-onset acid maltase deficiency. J Neurol Sci. 1990;98:169–83.CrossRefPubMedGoogle Scholar
- 3.Montagnese F, Granata F, Musumeci O, Rodolico C, Mondello S, Barca E, Cucinotta M, Ciranni A, Longo M, Toscano A. Intracranial arterial abnormalities in patients with late onset Pompe disease (LOPD). J Inherit Metab Dis. 2016;2(s1):S48.Google Scholar
- 4.Zhang B, Zhao Y, Liu J, Li L, Shan J, Zhao D, Yan C. Late-onset Pompe disease with complicated intracranial aneurysm: a Chinese case report. Neuropsychiatr Dis Treat. 2016;12:713–7.CrossRefPubMedPubMedCentralGoogle Scholar
- 5.Brettschneider J, Sperfeld AD, Ludolph AC, Kassubek J. Intracerebral hemorrhage in a patient with glycogenosis type II (Pompe disease): is there a pathophysiological relationship? Muscle Nerve. 2008;38:1211–2.CrossRefPubMedGoogle Scholar
- 6.Huded V, Bohra V, Prajapati J, DeSouza R, Ramankutty R: Stroke in young-dilative Arteriopathy: a clue to late-onset Pompe's disease? J stroke Cerebrovasc dis 2016.Google Scholar
- 7.Hensel O, Hanisch F, Stock K, Stoevesandt D, Deschauer M, Muller T. Morphology and function of cerebral arteries in adults with pompe disease. JIMD Rep. 2015;20:27–33.CrossRefPubMedPubMedCentralGoogle Scholar
- 8.Smoker WR, Corbett JJ, Gentry LR, Keyes WD, Price MJ, McKusker S. High-resolution computed tomography of the basilar artery: 2. Vertebrobasilar dolichoectasia: clinical-pathologic correlation and review. AJNR Am J Neuroradiol. 1986;7:61–72.PubMedGoogle Scholar
- 9.Hoogeveen RM, Bakker CJ, Viergever MA. Limits to the accuracy of vessel diameter measurement in MR angiography. J Magn Reson Imaging. 1998;8:1228–35.CrossRefPubMedGoogle Scholar
- 10.Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. In AJR Am J Roentgenol. 1987;149:351–6.CrossRefGoogle Scholar
- 11.Pichiecchio A, Sacco S, De Filippi P, Caverzasi E, Ravaglia S, Bastianello S, Danesino C. Late-onset Pompe disease: a genetic-radiological correlation on cerebral vascular anomalies. J Neurol. 2017;264(10):2110-18.Google Scholar
- 12.Hobson-Webb LD, Proia AD, Thurberg BL, Banugaria S, Prater SN, Kishnani PS. Autopsy findings in late-onset Pompe disease: a case report and systematic review of the literature. Mol Genet Metab. 2012;106:462–9.CrossRefPubMedGoogle Scholar
- 13.Katona I, Weis J, Hanisch F. Glycogenosome accumulation in the arrector pili muscle in Pompe disease. Orphanet J Rare Dis. 2014;9:17.CrossRefPubMedPubMedCentralGoogle Scholar
- 14.Samim M, Goldstein A, Schindler J, Johnson MH. Multimodality imaging of Vertebrobasilar Dolichoectasia: clinical presentations and imaging Spectrum. Radiographics. 2016;36:1129–46.CrossRefPubMedGoogle Scholar
- 15.Passero SG, Rossi S. Natural history of vertebrobasilar dolichoectasia. Neurology. 2008;70:66–72.CrossRefPubMedGoogle Scholar
- 16.Gutierrez J, Honig L, Elkind MS, Mohr JP, Goldman J, Dwork AJ, Morgello S, Marshall RS. Brain arterial aging and its relationship to Alzheimer dementia. Neurology. 2016;86:1507–15.CrossRefPubMedPubMedCentralGoogle Scholar
- 17.Roth W, Morgello S, Goldman J, Mohr JP, Elkind MS, Marshall RS, Gutierrez J. Histopathological differences between the anterior and posterior brain arteries as a function of aging. Stroke. 2017;48:638–44.CrossRefPubMedPubMedCentralGoogle Scholar
- 18.Ikeda K, Nakamura Y, Hirayama T, Sekine T, Nagata R, Kano O, Kawabe K, Kiyozuka T, Tamura M, Iwasaki Y. Cardiovascular risk and neuroradiological profiles in asymptomatic vertebrobasilar dolichoectasia. Cerebrovasc Dis. 2010;30:23–8.CrossRefPubMedGoogle Scholar
- 19.Hardy DG, Peace DA, Rhoton AL Jr. Microsurgical anatomy of the superior cerebellar artery. Neurosurgery. 1980;6:10–28.CrossRefPubMedGoogle Scholar
- 20.Garibaldi M, Sacconi S, Antonini G, Desnuelle C. Long term follow-up of cerebrovascular abnormalities in late onset Pompe disease (LOPD). J Neurol. 2017;264:589–90.CrossRefPubMedGoogle Scholar
- 21.Tanaka M, Sakaguchi M, Miwa K, Okazaki S, Furukado S, Yagita Y, Mochizuki H, Kitagawa K. Basilar artery diameter is an independent predictor of incident cardiovascular events. Arterioscler Thromb Vasc Biol. 2013;33:2240–4.CrossRefPubMedGoogle Scholar
- 22.Lou M, Caplan LR. Vertebrobasilar dilatative arteriopathy (dolichoectasia). Ann N Y Acad Sci. 2010;1184:121–33.CrossRefPubMedGoogle Scholar
- 23.Quenardelle V, Bataillard M, Bazin D, Lannes B, Wolff V, Echaniz-Laguna A. Pompe disease presenting as an isolated generalized dilative arteriopathy with repeated brain and kidney infarcts. J Neurol. 2015;262:473–5.CrossRefPubMedGoogle Scholar
- 24.Sandhu D, Rizvi A, Kim J, Reshi R. Diffuse cerebral microhemorrhages in a patient with adult-onset Pompe's disease: a case report. J Vasc Interv Neurol. 2014;7:82–5.PubMedPubMedCentralGoogle Scholar
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