Fig. 3 | Radiation Oncology

Fig. 3

From: Feasibility of a mini-pig model of radiation-induced brain injury to one cerebral hemisphere

Fig. 3

Histological changes in the pig brain after 25 Gy irradiation. The section was chosen to be in roughly the same location as the MRI data shown in Fig. 2. a Macroscopic examination is consistent with the MRI findings with mass effect and disrupted white matter. b Wide field picture of the Luxol-Fast Blue stained section shows clear demyelination of the left hemisphere as expected of RIBI. c × 10 magnification of the hematoxylin and eosin shows vascular changes and inflammatory infiltration suggestive of radiation necrosis. In the case of 15 Gy, wide field pictures of the H&E (d) and LFB (E) as well as × 10 magnification of the H&E (F) look normal

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