Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury

Fig. 2

Cardiomyocyte-restricted expression of misfolded CryABR120G protein enhanced I/R-induced neuroinflammation in the brain. a Diagram of the experimental design. b Immunofluorescence staining of GFAP in the peri-infarct zone brain of mice after MCAO. Scale bar, 50 μm. c Quantitative analysis of (b). d Immunofluorescence staining of Iba1 in the brain of mice after MCAO. Scale bar, 50 μm. e Quantitative analysis of (d). f Immunofluorescence of TNFα in the cortical infarct brain of mice after MCAO. Scale bar, 50 μm. g Quantitative analysis of (f). Data are shown as mean ± SD; for immunostaining, 10–16 sections per animal were imaged and analyzed using the ImageJ software. N = 3–4. *p < 0.05, **p < 0.01

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