Fig. 7 | Respiratory Research

Fig. 7

From: GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation

Fig. 7

GITRL stimulation inhibits Treg cell differentiation and promotes Th2 and Th17 cell differentiation. a Flow cytometry analysis of the percentage of CD4+CD25+Foxp3+ T cells (Tregs) in splenocytes stimulated with anti-CD3 or anti-CD3 plus GITRL. b Statistical analysis of (a) (n = 5 per group). c Flow cytometry analysis of the percentage of CD4+IL-4+ T cells (Th2), CD4+IFN-γ+ T cells (Th1) and CD4+IL-17+ T cells (Th17) in splenocytes stimulated with anti-CD3 or anti-CD3 plus GITRL. df Statistical analysis of (c) (n = 5 per group). gj Foxp3, GATA3, RORγt and T-bet mRNA expression in each group (n = 5 per group). *P < 0.05, ***P < 0.001

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