Fig. 3 | Respiratory Research

Fig. 3

From: GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation

Fig. 3

AAV-mediated GITRL knockdown reduces allergen-induced airway inflammation and airway hyperresponsiveness. a Representative hematoxylin and eosin (H&E) staining of lung sections in each group (× 200 magnification, scale bars = 500 μm). b Inflammation score in the airways and lungs (n = 5–6 per group). c Lung resistance to inhaled methacholine in each group (n = 4–6 per group). d Serum total IgE levels (n = 6–8 per group). e Total cells in bronchoalveolar lavage fluid (BALF) (n = 4–8 per group). f Total eosinophils in BALF (n = 4–8 per group). *P < 0.05, **P < 0.01, ***P < 0.001, HDM group versus Saline group; ^^P < 0.01, ^^^P < 0.001, HDM-challenged AAV-shGITRL group versus HDM-challenged AAV-GFP group

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