A = based on consistent and good quality patient-oriented evidence
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B = based on inconsistent or limited quality patient-oriented evidence
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C = based on consensus, usual practice, opinion, disease-oriented evidence or case series
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Quality of the evidence (QOE):
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1 = good quality, patient-oriented
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2 = limited quality, patient-oriented
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3 = other evidence (usual practice, opinion, disease oriented evidence)
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