Table 2 Lipids, CRP concentration and WOMAC score changes in patients treated with placebo and L-carnitine before and after 12 weeks of treatment

From: The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial

   L-carnitine group (n = 34) Pb Placebo group (n = 36) Pc Pd
LDL cholesterol (mg/dL) before 136.13 ± 43.71 0.240 126.92 ± 35.33 0.380 0.316
after 130.97 ± 29.46   122.94 ± 44.18   0.372
change −7.68 ± 37.07   −3.05 ± 20.59   0.525
HDL cholesterol (mg/dL) before 64.97 ± 26.35 0.434 64.08 ± 19.60 0.413 0.867
after 62.26 ± 11.35   67.94 ± 15.24   0.083
change −3.85 ± 8.35   2.5 ± 18.12   0.265
Triglycerides (mg/dL) before 185.53 ± 92.50 0.23 193.63 ± 80.05 0.888 0.684
after 169.15 ± 73.81   193.44 ± 78.60   0.188
change −20.50 ± 97.72   1.50 ± 63.18   0.265
Total cholesterol (mg/dL) before 226.74 ± 50.55 0.021 220.71 ± 42.70 0.259 0576
after 212.24 ± 41.39   210.89 ± 61.00   0.914
change −18.47 ± 44.33   −8.94 ± 46.77   0.385
CRP (mg/dL) before 3.40 ± 2.51b 0.142 3.9 ± 3.92 a 0.682 0.618
after 3.00 ± 3.05   4.40 ± 5.90   0.969
change −0.6 ± 2.52   0.09 ± 3.72   0.383
MDA (mg/dL) Before 33.3 ± 36.09 0.03 24.2 ± 14.7 0.36 0.36
After 26.1 ± 22.22   21.03 ± 11.4   0.76
change −5.22 ± 24.98   −2.08 ± 13.5   0.22
Pain index before 7.34 ± 3.4 0.001 8.63 ± 3.63 0.001 0.322
after 4.71 ± 2.65   5.89 ± 3.54   0.119
change −2.91 ± 2.03   −2.89 ± 2.21   0.964
Stiffness before 2.28 ± 1.72 0.001 3.02 ± 2.18 0.001 0.107
after 1.56 ± 1.50   2.00 ± 1.74   0.261
change −1 ± 1.00   −1.11 ± 1.43   0.223
Physical function before 17.82 ± 7.75 0.001 20.63 ± 8.77 0.001 0.142
after 11.15 ± 6.56   15.61 ± 8.17   0.014
change −6.97 ± 3.95   −5.11 ± 5.29   0.102
Global Score before 27.45 ± 11.44 0.001 32.29 ± 12.93 0.001 0.088
after 17.41 ± 9.81   23.50 ± 12.02   0.024
change −10.59 ± 5.58   −9.11 ± 6.44   0.342
  1. Mean ± SD (all such values)
  2. aMedian; IQR (all such values for non-normally distributed variables)
  3. bDetermined with the use of paired Student’s t tests for differences between baseline and follow-up in the L-carnitine group
  4. cDetermined with the use of paired Student’s t tests for differences between baseline and follow-up in the placebo group
  5. dDetermined with the use of independent samples t tests between L-carnitine and placebo groups