Fig. 1 | BMC Cancer

Fig. 1

From: Real-world safety of palbociclib in breast cancer patients in the United States: a new user cohort study

Fig. 1

Hazard Ratios of Acute Liver Injury (ALI)# in New Users of Palbociclib-Fulvestrant vs. New Users of Fulvestrant Monotherapy (historical comparator group)^*.

#ALI defined using the “primary ALI algorithm” defined in Supplemental Table 1.

^The unadjusted analysis was a comparison prior to propensity score matching.

*The propensity score included the following variables: age, region, DCI, number of outpatient visits, number of emergency room visits, secondary malignancy to lymph nodes of head, face, and neck, secondary malignancy to other specified sites, secondary malignancy to respiratory sites, tamoxifen, everolimus, anastrazole, denosumab or pamidronate, exemestane, chemotherapy, corticosteroids, diagnostic imaging, breast cancer surgery, letrozole, HER2+ therapy, radiation therapy, CT imaging, mammography, MRI imaging, anticonvulsants, antidepressants, sedatives/hypnotics, secondary malignancy to breast, breast cancer diagnosis code, in situ breast cancer diagnosis, hyperglycemia, cerebrovascular disease, chronic liver disease or Alcoholism, chronic or acute disease of gallbladder or pancreas, hepatic, biliary or pancreatic cancer, congestive heart failure, any medication associated with ALI, including acetaminophen, allopurinol, amiodarone, amitriptyline, clavulanic acid, aripiprazole, baclofen, ciprofloxacin, clindamycin, clopidogrel, duloxetine, estrogens, fluoxetine, ketoconazole, lisinopril, losartan, mirtazapine, nitrofurantoin, NSAIDs, omeprazole, paroxetine, phenothiazine, sertraline, statins, tetracycline, trazodone, and trimethoprim

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