Diagnostic value of metagenomic next-generation sequencing of bronchoalveolar lavage fluid for the diagnosis of suspected pneumonia in immunocompromised patients

Table 1 Characteristic of 69 immunocompromised patients

Characteristic	69 patients
Age (year), mean ± SD	57 ± 15
Gender, male, n (%)	44(64)
Immunocompromised status, n (%)
Hematologic malignancy	23(33)
Solid-organ transplantation	14(20)
Solid tumour receiving chemotherapy	5(7)
Immunosuppressive therapy^a	21(30)
Prolonged corticosteroid therapy^b	33(48)
Disease severity
PSI score, mean ± SD	127 ± 51
Invasive mechanical ventilation, n (%)	22(32)
Septic shock, n (%)	25(36)
Laboratory findings
WBC (10⁹/L), median (Q1, Q3)	6.58(4.93,11.05)
Neutrophils (10⁹/L), median (Q1, Q3)	5.66(3.23,9.39)
Lymphocyte count (10⁶/L), median (Q1, Q3)	0.73(0.35,1.17)
PaO₂/FiO₂, mean ± SD	196 ± 98
Albumin (g/L), mean ± SD	30 ± 7
Serum creatinine(mmol/L), median (Q1, Q3)	80(57, 127)
LDH (U/L), median (Q1, Q3)	432(304, 726)
CRP (mg/l), median (Q1, Q3)	88(42,149)
PCT (ng/ml), median (Q1, Q3)	0.27(0.11,1.20)
outcome
Total 30-day mortality, n (%)	14(20)

PSI pneumonia severity index, WBC white blood cell, LDH lactate dehydrogenase, CRP C-reactive protein, PCT procalcitonin
^aMore than 2 weeks. Underlying diseases include Dermatomyositis (2), Leukemia (1), connective tissue diseases (6), Solid-organ transplantation (9), Hemophilia (1), Chronic nephritic syndrome (1), Thrombocytopenia (1)
^bDefined as > 0.3 mg/kg/d of prednisone-equivalent for ≥ 3 weeks. Underlying diseases include Dermatomyositis (1), Connective tissue diseases (9), Solid-organ transplantation (10), Hemophilia (1), Nephrotic syndrome (6), Thrombocytopenia (1), interstitial lung disease (1), Hematologic malignancy (2), Intracranial tumour (1), Dermatology (1)