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Erratum to: On estimation of genetic variance within families using genome-wide identity-by-descent sharing

  • William G Hill
Open Access
Erratum
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Abstract

No abstract

Erratum

After publication of this work [1], regrettably I noted that there was an error in the examples given in Table 1, which was added when the paper was under revision and inadequately checked. A programming error led to incorrect calculations of within-family variances for full-sib families. Formulae and conclusions are unchanged.
Table 1

Comparison of var( ? ^ A 2 Open image in new window ) predicted from the information matrix directly and from the Taylor series approximation*

Family

HS

FS

FS

FS

FS

h 2

0.5

0.25

0.5

0.75

0.04

chr

22

22

22

22

1

n

5

15

25

5

15

25

5

15

25

5

15

25

5

15

25

Eq (A1)

174

12.2

4.15

82.2

5.82

1.97

60.7

4.39

1.52

42.2

3.09

1.09

4.69

0.347

0.125

Eq (1)

182

11.8

3.88

88.2

5.69

1.90

65.2

4.32

1.47

46.1

3.23

1.16

5.16

0.324

0.107

Eq (3)

182

11.7

3.80

88.1

5.69

1.88

64.7

4.18

1.47

44.9

2.90

0.96

5.15

0.323

0.107

*Predictions were obtained directly by inverting the realised information matrix (eq A1) obtained from sampling relationships, and from the Taylor series approximation eq. (1) using the variance of relationships directly. Variances, assuming ? p 2 = 1 Open image in new window, were computed by averaging information over samples of 100 families, but are expressed for a single family, so for f families var( ? ^ A 2 Open image in new window) should be divided by f. Predictions using the simplification eq. (3) are shown similarly; results are for half (HS) and full (FS) sib families; h2 is the proportion of variance contributed by the fitted chromosomes; chr is the number of chromosomes; chr?=?22 denotes the whole genome; chr?=?1 denotes a single chromosome.

The correct Table 1 is included here. Table title, headings and footnote are unchanged. Results are changed in columns 4 through 15 and indicated in bold characters.

References

  1. 1.
    Hill WG: On estimation of genetic variance within families using genome-wide identity-by-descent sharing. Genet Sel Evol. 2013, 45: 32-10.1186/1297-9686-45-32.PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Hill; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  1. 1.Institute of Evolutionary Biology, School of Biological SciencesUniversity of EdinburghEdinburghUK

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