Fig. 9 | Cancer Nanotechnology

Fig. 9

From: Targeting BMI-1 with PLGA–PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells

Fig. 9

The effect of Nano-PTC209 on glioblastoma stem-like cells (GSCs) and U87MG (U87) cell migration/invasion. a Cell migration was analyzed using a wound-healing assay. Representative images are presented after 4, 24, 48, and 72 h of GSCs and U87 treatment with Nano-PTC209 at different doses. The cell migration rate was estimated by the measurement of cell numbers within the wound region. b Effect of Nano-PTC209 on MMP-9 and MMP-2 secretions of GSCs and U8 cells. Areas and relative intensities of gelatin-digested bands by MMP-9 and MMP-2 were quantified using densitometry and presented as relative MMP-9 (left) and MMP-2 (right) activity compared with that of untreated cells. Data are presented as the mean ± SD. ** and *** indicate P < 0.01 and P < 0.001, respectively

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