Fig. 3 | Cancer Nanotechnology

Fig. 3

From: Targeting BMI-1 with PLGA–PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells

Fig. 3

Self-renewal capacity and characterization of glioblastoma stem-like cells (GSCs) derived from GBM tissues of patients. a The ability of GSCs in forming neurospheres under the serum-free medium was evaluated by a bright-field invert microscope. The bar graph shows the mean number of spheres after each passage. The proliferation capacity of GSCs was determined by the expression of Ki67. b Representative immunocytochemistry images show the expression of neural stem cell markers nestin and GFAP. The characterization of GSCs was also performed by flow cytometry. Representative dataset show the cells were positive for cancer stem cell markers CD44 and CD45 and negative for a hematopoietic marker CD34

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