Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder
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KeywordsIdiopathic Pulmonary Fibrosis Pulmonary Fibrosis Alveolar Epithelial Cell Animal Experimental Model Interstitial Pneumonitis
Idiopathic Pulmonary Fibrosis
The recent review by Selman and Pardo in this journal  correctly points out that in idiopathic pulmonary fibrosis (IPF) there is insufficient evidence to suggest that chronic inflammation plays a primary role in pathogenesis and that animal experimental models of pulmonary fibrosis therefore do not model IPF particularly accurately. However, the suggestion in the accompanying commentary by Gauldie and colleagues  that this "suggests a new hypothesis for the aetiology of this progressive and usually fatal disease" seems to be stretching the point.
In a review published in 1995, Kumar and Lykke  discussed lymphocyte-macrophage-fibroblast as well as epithelial cell-fibroblast and reciprocal interactions in pulmonary fibrosis. We stated that " [i]njury to alveolar epithelial cells, especially type 2 pneumocytes, appears to be an important event in the genesis of pulmonary fibrosis. Both in vitro and in vivo studies suggest that failure to replace damaged type 1 epithelium by proliferation and differentiation of type 2 pneumocytes may be a determinant of whether or not progression to fibrosis ensues." The references cited at this point included not only the studies by Adamson and colleagues  to which Selman and Pardo refer, but also data from an animal model of resolving vs. non-resolving pneumonia .
Furthermore, we discussed the alveolar epithelial changes in pulmonary fibrosis and pointed out that " [b]oth in animal experimental models and in the human disease, these cuboidal epithelial cells develop cytoplasmic extensions ('spikes') which protrude through the epithelial basement membrane. The spikes may become intimately associated with interstitial fibroblastic cells, a finding that is especially noticeable in 'usual interstitial pneumonitis' associated with epithelial hyperplasia. These observations strongly suggest that 'handshakes' between type 2 pneumocyte-like epithelial cells and fibroblasts might take place during the development of pulmonary fibrosis." This part of the review included references to numerous descriptions of such spikes in the 1980s literature, electron micrographs demonstrating the spikes both in IPF and in murine bleomycin-induced pulmonary fibrosis, and discussion of the potential role of epithelial cell-derived transforming growth factor-β (and other growth factors) in the induction of fibrosis.
Although this review was not published in a respiratory sciences journal, it has been cited in standard textbooks [6, 7], so one could reasonably argue that the concept of IPF as a disorder involving perturbed epithelial/fibroblastic cross-talk is not altogether novel.