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Genome Biology

, 3:spotlight-20020909-01 | Cite as

Pheromone phenotypes

  • Jonathan B Weitzman
Research news

Keywords

Sexual Behaviour Genomic Region Sensory Neuron Mutant Mouse Mouse Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

The V1r genes encode a large superfamily of receptors that are expressed in the sensory neurons of the vomeronasal organ (VNO) and are thought to be important in pheromone detection and responses. In the September 5 Nature, Del Punta et al. describe the phenotypes of mice lacking a large genomic region that contains V1r genes (Nature 2002, 419:70-74). They used the Cre-loxP system to engineer a 600 kb deletion in the mouse genome, removing a cluster of 16 genes (12% of the functional V1r repertoire). The mutant mice displayed defects in a subset of VNO-dependent behaviours, including reduced maternal aggression towards intruders and dysfunctions in male sexual behaviour. The deletion also abolished the electrophysiological response of the VNO to a subset of V1r ligands (the authors use the term "specific avnosmia").

References

  1. 1.
    A novel family of genes encoding putative pheromone receptors in mammals.Google Scholar
  2. 2.
    The vomeronasal organ.Google Scholar
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    Engineering chromosomal rearrangements in mice.Google Scholar

Copyright information

© BioMed Central Ltd 2002

Authors and Affiliations

  • Jonathan B Weitzman

There are no affiliations available

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