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Genome Biology

, 3:spotlight-20020418-01 | Cite as

CDK7 in C. elegans

  • Jonathan B Weitzman
Research news
  • 371 Downloads

Keywords

Normal Cell Dual Role mRNA Synthesis Lethal Mutant Cell Ploidy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

CDK7 is a kinase that is thought to play dual roles in transcription and cell-cycle regulation by phosphorylating the carboxy-terminal domain of RNA polymerase II and also phosphorylating other cyclin-dependent kinases (CDKs). In the April 16 Proceedings of the National Academy of Sciences, Wallenfang and Seydoux at the Johns Hopkins University School of Medicine describe a study of the C. elegans cdk-7 gene (Proc Natl Acad Sci USA 2002, 99:315-320). They conducted a genome-wide screen for temperature-sensitive (ts) embryonic lethal mutants affecting transcription and came up with a ts allele of cdk-7. The cdk-7 ts mutants displayed defects in mRNA synthesis and RNA polymerase phosphorylation, as well as independently regulating cell-cycle progression. They also found that cdk-7 is essential in the worm for meiosis and for maintaining normal cell ploidy.

References

  1. 1.
    Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control?Google Scholar
  2. 2.
    Proceedings of the National Academy of Sciences, [http://www.pnas.org]
  3. 3.
    Johns Hopkins Medical Institutions , [http://www.jhmi.edu]

Copyright information

© BioMed Central Ltd 2002

Authors and Affiliations

  • Jonathan B Weitzman

There are no affiliations available

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