Advertisement

Genome Biology

, 2:spotlight-20011026-01 | Cite as

Lining-up Listeria genomes

  • Jonathan B Weitzman
Research news
  • 294 Downloads

Keywords

Comparative Analysis Transcriptional Regulator Virulence Gene Surface Protein Transport Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Listeriosis is caused by the ingestion of pathogenic Listeria monocytogenes in contaminated food. In the October 26 Science, Glaser et al. report a comparative analysis of Listeria genomes aimed at identifying virulence genes (Science 2001, 294:849-852). They sequenced the genomes of two Listeria strains; pathogenic L. monocytogenes EGD-e and a non-virulent species L. innocua. L. monocytogenes contains a single circular chromosome of 2.9 Mb, while L. innocua has a 3 Mb chromosome and an 80 kb plasmid. The two genomes encode similar numbers of genes: almost 3000 open reading frames, of which a third code for proteins with no known, or predicted, function. The two genomes encode large numbers of putative surface proteins, transport proteins and transcriptional regulators. Many of these are likely to account for virulence and for the adaptability of Listeria species to diverse environmental conditions. Glaser et al. identified hundreds of strain-specific genes, which are clustered in islets. They conclude that their study "opens new avenues for post-genomic analysis of the life-styles of L. monocytogenes in the environment and the infected host."

References

  1. 1.
    Listeria pathogenesis and molecular virulence determinants.Google Scholar
  2. 2.

Copyright information

© BioMed Central Ltd 2001

Authors and Affiliations

  • Jonathan B Weitzman

There are no affiliations available

Personalised recommendations