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Genome Biology

, 2:spotlight-20010703-02 | Cite as

Deadly fusion

  • Jonathan B Weitzman
Research news

Keywords

Bacterial Artificial Chromosome Chromatin Remodelling Chromosomal Translocation Nature Genetic Cloning Strategy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Acute megakaryoblastic leukemia (AMKL) kills its young victims within a matter of months; and AMKL is associated with a chromosomal translocation t(1;22)(p13;q13). In the July issue of Nature Genetics, Ma et al. report the identification of two novel genes that are fused at the translocation breakpoint (Nature Genetics 2001, 28:220-221). They used a cloning strategy based on fluorescence in situ hybridization (FISH) to define the breakpoint and to recover bacterial artificial chromosome (BAC) clones covering the region. From these, they cloned a chromosome 22 gene, named MKL1 (megakaryoblastic leukemia-1) that contains a SAP DNA-binding motif and may be involved in chromatin remodelling. MKL1 is fused to a gene on chromosome 1 called RBM15 (RNA-binding motif protein 15); it encodes RNA-recognition motifs and resembles the Drosophila gene spen. The authors speculate that the RMM15-MKL1 fusion protein causes aberrant RNA processing and signalling that disrupts megakaryoblast differentiation and/or proliferation.

References

  1. 1.
    Acute megakaryocytic leukemia with the t(1;22)(p13;q13)Google Scholar
  2. 2.
    Nature Genetics , [http://genetics.nature.com]
  3. 3.
    SAP - a putative DNA-binding motif involved in chromosomal organization.Google Scholar
  4. 4.
    Conserved structures and diversity of functions of RNA-binding proteins.Google Scholar

Copyright information

© BioMed Central Ltd 2001

Authors and Affiliations

  • Jonathan B Weitzman

There are no affiliations available

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