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Genome Biology

, 1:spotlight-20001211-01 | Cite as

Slimy catenins

  • William Wells
Research news
  • 342 Downloads

Keywords

Gene Expression Arabidopsis Thaliana Fruiting Body Related Protein Adherens Junction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

In the 7 December Nature Grimson et al. report that, like metazoans, the slime mold Dictyostelium discoideum has a β-catenin involved both in signaling and in forming adherens junctions (Nature 2000, 408:727-731). The junctions form after the unicellular amoebae are starved and aggregate into a fruiting body, with junctions present only between cells at a constriction near the top of the stalk tube. In mutants lacking the β-catenin, most of the fruiting bodies collapse, and there is an additional signaling defect: a cell-autonomous failure to induce certain aspects of prespore gene expression. The existence of the Dictyostelium protein and a related protein in the plant Arabidopsis thaliana suggest that evolution of β-catenin may have been a prerequisite for all multicellular development.

References

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  2. 2.
    Functional interaction of beta-catenin with the transcription factor LEF-1.Google Scholar
  3. 3.
    The molecular constituents of intercellular junctions.Google Scholar

Copyright information

© BioMed Central Ltd 2000

Authors and Affiliations

  • William Wells

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