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Genome Biology

, 1:spotlight-20000804-01 | Cite as

The two chromosomes of cholera

  • William Wells
Research news
  • 275 Downloads

Keywords

Regulatory Protein Cholera Complete Sequence Genomic Research Essential Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

In the 3 August Nature, The Institute for Genomic Research (TIGR) has unveiled its twentieth completed bacterial sequence (Heidelberg et al., Nature 2000, 406:477-484). The complete sequence of the cholera-causing bacterium Vibrio cholerae consists of the 2.96 Mbp chromosome 1 and the 1.07 Mbp chromosome 2. Chromosome 1 contains a standard bacterial origin of replication and the vast majority of the bacterium's essential genes, whereas chromosome 2 has an origin of replication and various genes that are usually associated with plasmids, and thus may have started life as a megaplasmid. The two chromosome have, however, coexisted for a long time based on their almost identical G+C content. Moreover, chromosome 2 now has several essential genes, and a number of regulatory proteins control genes on both chromosomes. The bacterium's strategies for coordinating replication and segregation of the two chromosomes remain to be established.

References

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    The Institute for Genomic Research, [http://www.tigr.org]

Copyright information

© BioMed Central Ltd 2000

Authors and Affiliations

  • William Wells

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