C1-esterase inhibitor (C1INH) implication in systemic inflammation in sepsis
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KeywordsPublic Health Septic Shock Healthy Individual Emergency Medicine Systemic Activity
C1INH is the most potent endogenous regulator of compliment as well as intrinsic coagulation pathways and the kallekrein-kinin system.
C1INH systemic activity was studied in patients who were enrolled within 48 hours after onset of sepsis (ACCP, 1992). The analysis of C1INH activity in quartiles (Q) was conducted in terms of RCT of human purified C1INH (Bicizar, Russia).
Inability to upregulate C1INH activity in sepsis was associated with enhanced systemic inflammation, higher number of ARDS and septic shock cases.