Early hydrocortisone treatment counteracts circulatory derangement but not cytokine response in porcine endotoxemia
- 1.5k Downloads
KeywordsHydrocortisone Arterial Pressure Core Temperature Resistance Index Systemic Vascular Resistance
We evaluated whether treatment with hydrocortisone administered just after establishment of endotoxin-mediated circulatory dysfunction would have anti-inflammatory and shock reversing effects. Establishment of endotoxin-mediated circulatory dysfunction was defined as the moment when the mean pulmonary arterial pressure (MPAP) reached the double baseline value.
All pigs were anesthetized and given endotoxin infusion during the 6 hours of the experiment. Eight pigs were randomized to the hydrocortisone group, receiving hydrocortisone at 5 mg/kg intravenously, or to the control group, receiving a corresponding volume of saline, as soon as the MPAP doubled the baseline value. P < 0.05 was considered significant.
Early treatment with hydrocortisone, administered after the onset of endotoxemia, counteracted circulatory deterioration, but did not affect the plasma levels of proinflammatory cytokines in this model. Thus, TNFα and IL-6 might not be involved in the development of circulatory dysfunction during the early phase of experimental endotoxemia.