Characterization of organophosphate poisoning patients in the ICU: a 4-year review
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KeywordsAtropine Simplify Acute Physiology Score Continuous Intravenous Infusion Dimethoate Acute Physiology Score
We reviewed clinical characterization of patients with organophosphate poisoning admitted to the ICU as well as the mortality rate .
A retrospective study, without need for local ethical committee approval, of patients with organophosphate poisoning who were admitted to the ICU between 2004 and 2008. Sociodemographic data, psychiatric history, the organophosphate compound, time elapsed since ingestion, clinical presentation and complications, laboratory data, Simplified Acute Physiology score (SAPS) II and treatment approach were analyzed. Biomarkers used on admission: serum cholinesterase level, arterial pH and lactic acid. The influence of obidoxime and atropine therapy on the patient outcome was also analyzed.
Clinical severity and serum cholinesterase levels and acidosis were the independent variables that mostly seemed to have contributed for the final result. High doses of atropine seemed to be more favorable to a good outcome. Even though the number of patients included in this review was small, the results may alert us to the importance of an organized approach helped by protocols between the emergency department/emergency room and the ICU, in order to successfully manage patients with organophosphate poisoning.
This article is published under license to BioMed Central Ltd.