Angiopoietin-2 is a mediator involved in the advent of hypotension following endotoxin shock
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KeywordsPublic Health Escherichia Coli Catheter Endothelial Cell Emergency Medicine
Angiopoietin-2 (Ang-2) is a mediator produced by endothelial cells . It is in doubt whether its production in the intubated septic host is due to an effect of anesthetic medication or to the sepsis process. The present study attempted to provide an answer.
In 10 mechanically ventilated pigs, anesthesia was maintained by sevoflurane inhalation. Then shock was induced by the intravenous administration of 25 mg/kg lipopolysaccharide (LPS) of Escherichia coli 111: B4 in eight pigs; two were controls. Blood was collected by a Swan–Ganz catheter and by a peripheral vein. Ang-2 was estimated by an enzyme immunoassay.
The median Ang-2 of the peripheral circulation among controls and pigs at shock was at baseline 1,403.2 and 2,390.6 pg/ml (P = NS), respectively; at 1 hour 914.2 and 2,192.5 pg/ml (P = 0.048), respectively; and at 2 hours 2,013 and 1,738.7 pg/ml (P = NS). Respective values of the lung circulation were 995.8 and 1,738.7 pg/ml at baseline (P = NS); 831.3 and 1,663.3 pg/ml at 1 hour (P = NS); and at 2 hours 943.8 and 1,757.8 pg/ml (P = NS).
Ang-2 is a mediator involved in the advent of shock not influenced by the administration of sevoflurane.
This article is published under license to BioMed Central Ltd.