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Critical Care

, 4:P23 | Cite as

Newly developed thrombocytopenia in medical intensive care patients

  • R Strauss
  • M Wehler
  • K Mehler
  • D Kreutzer
  • A Mueller
  • P Martus
  • EG Hahn
Meeting abstract
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Keywords

Public Health Observational Study Clinical Setting Care Patient Platelet Count 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Full text

Introduction

Thrombocytopenia is a major concern in intensive care medicine. The incidence is greatly varying depending on the clinical setting.

Objective

To determine the incidence, severity, prognosis and therapeutic implications of thrombocytopenia in our 12-bed medical (noncoronary) ICU.

Methods

We evaluated, in a prospective observational study over 13 months (1.11.1997-30.11.1998), all patients who stayed longer than 48 h in the ICU. Thrombocytopenia was defined as a platelet count below 150000/μl.

Results

We studied 243 patients (63.3% male) with a mean age of 57.9 (± 16.34, 18-96) years, a mean APACHE II score of 21.2 (± 10.06, 0-49) and a mean length of stay of 13.5 days. Thrombocytopenia was observed frequently: only 82 patients (33.7%) were never thrombocytopenic. Ninety-nine (40.7%) patients were thrombocytopenic on admission. From the 144 patients who had normal platelets on admission 62 (45.2%) developed thrombocytopenia. In this group of patients, ICU mortality was significantly correlated with the degree of thrombocytopenia: 66.7% in patients with platelets <20000/μl, 55.6% in patients with platelets 20000-50000, 47.4% in patients with platelets 50000-100000, 9.7% in patients with platelets 100000-150000 (P=0.003 χ2).

Conclusion

45.2% of patients became thrombocytopenic during their ICU stay. The degree of newly developed thrombocytopenia was highly correlated with mortality, length of stay, initial APACHE II score and the consumption of blood products.

Table

Platelets during the ICU stay

      
  

Packed red blood cells

FFPs

SDAP (platelets)

SOFA on

APACHE II

Length of stay

/Χl

N

units

units

units

admission

on admission

days

100 001-150 000

31

  2.29± 4.03

0

0

4.81± 2.70

21.42± 9.56

17.06± 18.88

50 001-100 000

19

  3.58± 5.67

  2.84± 5.40

0.05± 0.23

6.63± 2.93

27.00± 8.08

13.79± 11.02

20 000-50 000

9

10.00± 7.45

  4.22± 7.03

0.67± 1.12

7.67± 2.87

  25.78± 12.22

23.22± 27.92

<20 000

3

  28.33± 18.18

17.67± 4.73

6.67± 5.51

8.67± 3.21

35.00± 6.93

55.67± 64.63

P

 

<0.001

0.027

0.003

0.075

0.002

<0.001

All data mean ± standard deviation. ANOVA was used for testing.

Copyright information

© Current Science Ltd 2000

Authors and Affiliations

  • R Strauss
    • 1
  • M Wehler
    • 1
  • K Mehler
    • 1
  • D Kreutzer
    • 1
  • A Mueller
    • 1
  • P Martus
    • 2
  • EG Hahn
    • 1
  1. 1.Department of Medicine IUniversity Erlangen-NurembergErlangenGermany
  2. 2.Biometry and Epidemiology,Krankenhausstrasse 12University Erlangen-NurembergErlangenGermany

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