Effects of epidural and halothane anaesthesia on vasoconstrictive properties of cell-free haemoglobin
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KeywordsArterial Pressure Halothane Bupivacaine Cardiac Index Clinical Investigation
In the moment haemoglobin based oxygen carries (HBOC) are under clinical investigation. Only few studies looked for the interactions between anaesthetic drugs and HBOC. The effects of HBOC during regional anaesthesia have never been analysed. Therefore, we investigated the hemodynamic changes after HBOC infusion during different kinds of anaesthesia.
Sheep were assigned to three different groups: a) 6 not anaesthetised sheep, b) 6 sheep with a halothane anaesthesia (2.0 Vol. % in oxygen), c) 6 sheep had an thoracic epidural anaesthesia with bupivacaine. After a stabilisation period all 18 animals received an i.v. bolus of 100 mg Pyridoxalated Haemoglobin Poly-oxyethylene Conjugate/kg.
The selection of the anaesthesia method may alter hemodynamic side effects of HBOC.