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Critical Care

, 1:P040 | Cite as

Administration of amphotericin B in lipid emulsion decreases nephrotoxicity: a controlled study in critically ill patients

  • P Sorkine
  • H Nagar
  • A Weinbroum
  • A Setton
  • E Israitel
  • A Scarlatt
  • A Silbiger
  • V Rudick
  • Y Kluger
  • P Halpern
Meeting abstract

Keywords

Lipid Liver Function Thrombocytopenia Emergency Medicine Lower Incidence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Objective

To evaluate the differences in administered in a lipid emulsion compared to amphotericin B (AmpoB) in dextrose 5%, for the treatment of Candida albicans infection.

Sixty consecutive critically ill patients with confirmed or suspected Candida infection received AmphoB (1 mg/kg/24 h) administered randomly in either dextrose 5% (group A) or in lipid emulsion (20% Intralipid®) (group B).

Measurements and main results

Clinical tolerance (fever, chills, hemodynamics), liver function tests, electrolytes and coagulation profile were evaluated. Patients receiving AmphoB in lipid emulsion experienced a lower incidence of drug-associated fever (61.4% versus 5.8%, P < 0.003), rigors (54% versus 8.5%, P < 0.004), hypotension (17% versus 0%) and nephrotoxicity. Significant thrombocytopenia (264,500 ± 71,460/mm3 to 163,570 ± 34,450/mm3, P < 0.01), not associated with active bleeding, occurred with AmphoB-lipid emulsion but not with the dextrose regimen.

Conclusions

Treatment with AmphoB-lipid emulsion of critically ill patients with Candida infection seems to be safer and as effective as the conventional mode of administration.

Copyright information

© Current Science Ltd 1997

Authors and Affiliations

  • P Sorkine
    • 1
  • H Nagar
    • 1
  • A Weinbroum
    • 1
  • A Setton
    • 1
  • E Israitel
    • 1
  • A Scarlatt
    • 1
  • A Silbiger
    • 1
  • V Rudick
    • 1
  • Y Kluger
    • 1
  • P Halpern
    • 1
  1. 1.Departments of Anesthesiology and SurgerySourasky Medical Center, Tel Aviv UniversityTel-AvivIsrael

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