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Critical Care

, 8:P244 | Cite as

Intravenous paracetamol (Prodafalgan) causes hypotension in critically ill patients

  • M Hersch
  • L Kanter
  • M Gurevitz
  • D Raveh
Poster presentation

Keywords

Public Health Blood Pressure Heart Rate Noradrenaline Emergency Medicine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

Some critically ill patients cannot absorb enteral medications. We noted that intravenous (IV) Prodafalgan (PRDFG), a recently introduced parenteral bioprecursor of paracetamol, caused hypotension. A prospective study was conducted.

Methods

The population was ICU patients requiring IV PRDFG (rectal temperature ≥ 38°C, no enteral route). PRDFG (2 g) was infused over 15–20 min. The temperature, heart rate, systolic/diastolic blood pressure and mean blood pressure (MAP) were recorded before, during and 15–120 min following infusion. Interventions to correct hypotension were recorded.

Results

Seventy-two events, in 14 patients, of PRDFG administration were recorded. MAP dropped significantly 15 min following PRDFG infusion. Initiation or increase of noradrenaline occurred in 25% of the events and fluid bolus was given in 8%.

Conclusions

PRDFG caused significant hypotension, requiring active intervention in 33% of the events. This data substantiated the anecdotal knowledge on the relationship between paracetamol (acetaminophen) and hypotension in the critically ill and associated it with the IV preparation.

Figure 1

Copyright information

© BioMed Central Ltd. 2004

Authors and Affiliations

  • M Hersch
    • 1
  • L Kanter
    • 1
  • M Gurevitz
    • 1
  • D Raveh
    • 1
  1. 1.Shaare Zedek Medical CentreIsrael

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