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Critical Care

, 2:P056 | Cite as

Continuous infusion of propofol for sedation of pediatric patients following open-heart surgery

  • A Darwish
  • S Mousa
  • B Afrane
  • M El-Barbary
  • Z Halees
Meeting abstract
  • 1k Downloads

Keywords

Congenital Heart Disease Sedative Agent Blood Oxygen Saturation Continuous Sedation Partial Carbon Dioxide Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

The aim of this study was to prospectively evaluate safety and efficacy of propofol infusion as an alternative sedative agent in children with open-heart surgery.

Methods

Twenty-nine pediatric patients with complex congenital lesions, aged between 4 and 48 months, who underwent open-heart surgery, received propofol infusion as sedation after midazolam infusion was ineffective. The effective sedative dose of propofol was between 1.5 and 7.0 mg/kg per h (median 3 mg/kg per h). Measurement of heart rate (HR) electrocardiogram (ECG), blood pressure (BP), arterial blood gas (ABG) including pH, bicarbonate (HCO3), partial carbon dioxide pressure (PCO2), and blood oxygen saturation (PO2); and blood chemistry including liver function tests (LFTs), triglycerides (TG), and total bilirubin (TB), were all done prior to and during propofol therapy.

Results

After 10–288 h of propofol infusion (median 74 h), no statistically significant differences were found in the parameters measured except a decrease in median HR with attendant decrease in BP, and an increase in median TG.

Conclusion

Continuous sedation with propofol is a safe and effective, alternative agent for sedation of infants and children after surgical repair of compex congenital heart disease.

Table

Parameter

Change in median values

P values

HR (beats/min)

-10

0.009

BP (mmHg)

-2

0.001

Triglyceride (mmol/l)

0.2

0.001

Copyright information

© Current Science Ltd 1998

Authors and Affiliations

  • A Darwish
    • 1
  • S Mousa
    • 1
  • B Afrane
    • 1
  • M El-Barbary
    • 1
  • Z Halees
    • 1
  1. 1.King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia

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