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Critical Care

, 19:P462 | Cite as

Hydroquinone shows neuroprotective potential in an experimental ischemic stroke model via attenuation of blood-brain barrier disruption

  • JH Cho
  • CW Park
  • TG Ohk
  • MC Shin
  • MH Won
Open Access
Poster presentation

Keywords

Ischemic Stroke Neuroprotective Effect Hydroquinone Post Treatment Focal Cerebral Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

Hydroquinone (HQ), a major benzene metabolite, occurs naturally in various plants and food, and is also manufactured for commercial use. Although many studies have demonstrated the various biological effects of HQ, the neuroprotective effects of HQ following ischemic stroke have not been investigated. Therefore, in this study, we first examined the neuroprotective effects of HQ against ischemic damage in a focal cerebral ischemia rat model.

Methods

It was proven that pre and post treatment with 100 mg/ kg HQ protects from ischemia-induced cerebral damage, which was confirmed by evaluation of neurological deficit, positron-emission tomography and 2,3,5-triphenyltetrazoliumchloride staining.

Results

In addition, pre and post treatment with 100 mg/kg HQ significantly attenuated ischemia-induced Evans blue dye extravasation, and significantly increased the immunoreactivities and protein levels of SMI-71 and glucose transporter-1 (GLUT-1), which were well known as useful makers of endothelial cells, in ischemic cortex compared with a vehicle-treated group.

Conclusion

Briefly, these results indicate that pre and post treatment with HQ can protect from ischemic damage induced by transient focal cerebral ischemia, and the neuroprotective effects of HQ may be closely associated with the prevention of BBB disruption via increase of SMI-71 and GLUT-1 expressions.

Copyright information

© Cho et al.; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • JH Cho
    • 1
  • CW Park
    • 1
  • TG Ohk
    • 1
  • MC Shin
    • 1
  • MH Won
    • 1
  1. 1.Kangwon National UniveristyChuncheon-siSouth Korea

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