Urinary TIMP-2 and IGFBP7 elevate early in critically ill postoperative patients that develop AKI
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KeywordsPublic Health Temporal Change Emergency Medicine Sapphire Major Surgery
Little is known about temporal changes in [TIMP2·IGFBP7] relative to injury in patients who develop AKI. In this analysis, we examined [TIMP-2·IGFBP7] in serial urine collections from the subset of Sapphire patients who were admitted to the ICU after major surgery.
We stratified 238 Sapphire patients into three groups by their maximum AKI stage within 48 hours of the start of surgery using KDIGO criteria (No AKI, KDIGO 1, and KDIGO 2 to 3). Median TIMP-2·IGFBP7 values were calculated from all samples collected at 12 (±6)-hour intervals for 4 days following the start of surgery.
Urinary [TIMP-2·IGFBP7] was significantly elevated as early as 12 to 24 hours from the start of surgery in patients who developed AKI within 48 hours. Monitoring of these biomarkers in the immediate postsurgical period might enable improved management of patients at risk for AKI.
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