Prognostic value of procalcitonin in respiratory tract infections across clinical settings
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KeywordsTreatment Failure Lower Respiratory Tract Prognostic Information Procalcitonin Lower Respiratory Tract Infection
Whether the inflammatory biomarker procalcitonin (PCT) provides prognostic information across clinical settings and different acute respiratory tract infections (ARI) is poorly understood. Herein, we investigated the prognostic value of admission PCT levels to predict adverse clinical outcome in a large ARI population.
We analyzed data from 14 trials and 4,211 ARI patients to study associations of admission PCT levels and setting specific treatment failure and mortality alone at 30 days. We used multivariable hierarchical logistic regression and conducted sensitivity analyses stratified by clinical settings and ARI diagnoses to assess the results' consistency.
Admission PCT levels are associated with setting specific treatment failure and provide most prognostic information in ARI in the emergency department setting.
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