Clinical usefulness of measurement of plasma soluble fibrin levels in critically ill patients
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KeywordsThrombin Fibrinogen Clinical Usefulness Blood Coagulation Entire Study
The soluble fibrin monomer fibrinogen complex (SF) is a complex coupling fibrin monomer and fibrinogen molecules. As the level of SF reflects the thrombin generation activity in plasma, we may estimate the early-activated state of blood coagulation by the measurement of SF. The aim of this study is to evaluate the clinical usefulness of SF for the hypercoagulated state.
We measured the plasma level of SF in 63 patients within 48 hours after admission and on the 1st, 3rd, 5th and 7th days after admission. Underlying disease mainly includes sepsis, shock, and so on. According to the disseminated intravascular coagulation diagnostic criteria established by the Japanese Association of Acute Medicine, we defined the DIC group as JAAM-DIC score more than 3 within 48 hours after admission, the Subclinical DIC group as score more than 3 within 7 days beyond 48 hours after admission, and the No DIC group as score less than 4 during the entire study period. The SF value of each group was compared with the Mann-Whitney U test.
We think measurement of the plasma SF level may be clinically useful in evaluating the severity of critically ill patients such as those with sepsis.
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