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Critical Care

, 16:P442 | Cite as

Blood transfusion is an independent predicting factor for poor outcome after cardiac surgery

  • J Almeida
  • S Zeferino
  • F Galas
  • J Fukushima
  • L Camara
  • M Lima
  • T Santos
  • M Ferreira
  • J AulerJr
  • R Kalil Filho
  • L Hajjar
Poster presentation

Keywords

Blood Transfusion Transfuse Patient Supraventricular Tachyarrhythmia Cardiac Syndrome Postoperative Severe Complication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

Blood transfusion is associated with worse outcome in critically ill patients. A restrictive strategy of blood transfusion has been advocated in patients undergoing cardiac surgery in order to avoid clinical complications related to exposure to blood components. Nevertheless, the blood transfusion rate remains elevated in clinical practice.

Methods

We performed a retrospective study with 750 patients undergoing elective coronary arterial graft bypass (CABG) surgery, valvar surgery or combined procedure under cardiopulmonary bypass (CPB) between October 2010 and October 2011 at a university hospital cardiac surgery referral center in Brazil. We collected baseline characteristics and preoperative laboratory data, EuroSCORE, type of surgical procedure, intraoperative characteristics, blood transfusion exposure, postoperative severe complication as bleeding, low output cardiac syndrome, vasoplegia syndrome, myocardial ischemia, stroke, ventricular or supraventricular tachyarrhythmia, respiratory failure, acute renal failure, infection, ICU length of stay, hospital length of stay and mortality in 30 days.

Results

A total of 512 patients (68.4%) was exposed to blood transfusion components. Transfused patients presented a higher number of severe clinical complications in the postoperative period compared to nontransfused patients (74 (34.1%) vs. 312 (61.9%), P < 0.0001). Also, the mortality rate was higher in transfused patients than nontransfused patients (1 (0.5%) vs. 18 (3.6%), P < 0.016). In a multivariate analysis, age, obesity, perioperative myocardial ischemia, valve disease, heart failure, blood transfusion and CPB duration are independently associated with mortality.

Conclusion

Blood component exposure is associated with poor outcome and mortality in patients undergoing cardiac surgery. Despite the evidence that blood transfusion is associated with worse outcome, the blood transfusion rates remain unacceptably high in clinical practice.

References

  1. 1.
    Hajjar LA, Vincent JL, Galas FR, Nakamura RE, Silva CM, Santos MH, et al.: Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA 2010, 304: 1559-1567. 10.1001/jama.2010.1446CrossRefPubMedGoogle Scholar

Copyright information

© Almeida et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • J Almeida
    • 1
  • S Zeferino
    • 1
  • F Galas
    • 1
  • J Fukushima
    • 1
  • L Camara
    • 1
  • M Lima
    • 1
  • T Santos
    • 1
  • M Ferreira
    • 1
  • J AulerJr
    • 1
  • R Kalil Filho
    • 1
  • L Hajjar
    • 1
  1. 1.Heart InstituteSão PauloBrazil

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