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Critical Care

, 16:P201 | Cite as

Human protein C concentrate to restore physiological values in adult septic shock patients: effects on microcirculation

  • A Morelli
  • A Donati
  • A Di Russo
  • F D'Ippolito
  • C Raffone
  • A D'Egidio
  • MR Lombrano
  • S Tondi
  • E Damiani
  • V Cecchini
  • A Orecchioni
  • P Pietropaoli
Poster presentation
  • 782 Downloads

Keywords

Cardiac Output Emergency Medicine Plasma Protein Standard Treatment Continuous Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

We investigated whether human protein C (PC) concentrate to restore physiological values in adult septic shock patients can influence microcirculatory blood flow.

Methods

We enrolled 36 septic shock patients with plasma protein C activity <60%. Patients were randomly allocated to be treated with either a continuous infusion of PC concentrate at 3 UI/kg/hour for 72 hours to reach plasma protein C activity between 70 and 120% or a standard treatment (control; each n = 18). In both groups, NE was titrated to achieve a MAP between 65 and 75 mmHg. Data from right heart catheterization and sidestream dark-field imaging were obtained at baseline and after 24, 48 and 72 hours.

Results

For the same MAP and cardiac output, no significant differences were found between groups in terms of microvascular flow index of the small vessels (MFIs) and perfused vessel density (PVD). Results are summarized in Table 1.
Table 1

Microcirculatory variables

 

Baseline

24 hours

48 hours

72 hours

MFIs

    

Treated

2.8(2.6; 3)

3 (2.7; 3)

2.9 (2.8; 3)

3 (2.9; 3)

Controls

2.8 (2.1; 2.9)

2.8 (2.1; 2.8)

2.8 (2.2; 3)

3 (2.6; 3)

PVD

    

Treated

17.8 (16.5; 22.2)

19.7 (17.4; 22.5)

19.7 (18.1; 23)

19.9 (17; 22.2)

Controls

20.2 (17.4; 23.5)

18.8 (17.6; 20.2)

19.4 (17.5; 20.7)

18.7 (17.5; 21.2)

Conclusion

The administration of human PC concentrate did not influence microcirculatory blood flow in septic shock patients.

Copyright information

© Morelli et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • A Morelli
    • 1
  • A Donati
    • 2
  • A Di Russo
    • 1
  • F D'Ippolito
    • 1
  • C Raffone
    • 1
  • A D'Egidio
    • 1
  • MR Lombrano
    • 2
  • S Tondi
    • 2
  • E Damiani
    • 2
  • V Cecchini
    • 1
  • A Orecchioni
    • 1
  • P Pietropaoli
    • 1
  1. 1.University La SapienzaRomeItaly
  2. 2.Marche Polytechnique UniversityAnconaItaly

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