High levels of B-type natriuretic peptide predict weaning failure from mechanical ventilation in adult patients after cardiac surgery
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KeywordsMechanical Ventilation Coronary Artery Bypass Grafting Artery Bypass Coronary Artery Bypass Predictor Factor
Failure to wean from mechanical ventilation is related to worse outcomes after cardiac surgery. The aim of the study was to evaluate B-type natriuretic peptide (BNP) as a predictor factor of failure to wean from mechanical ventilation after cardiac surgery.
We conducted a prospective and observational cohort study of 101 patients that underwent on-pump coronary artery bypass grafting. BNP was measured postoperatively after ICU admission and at the end of a spontaneous breathing test (SBT). Demographic data, hemodynamic and respiratory parameters, fluid balance, need for vasopressor or inotropic support, lengths of ICU and hospital stay were recorded. Weaning failure was considered as either the inability to sustain spontaneous breathing after 60 minutes or the need for reintubation within 48 hours.
BNP was an independent predictor factor of failure to wean from mechanical ventilation after cardiac surgery, which suggests that optimization of the ventricular function must be a goal prior to liberation from mechanical ventilation.
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