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Breast Cancer Research

, 7:P5.04 | Cite as

Monitoring of minimal residual cancer in bone marrow in high-risk breast cancer patients treated with high-dose chemotherapy

  • V Drageset
  • JM Nesland
  • B Erikstein
  • E Skovlund
  • H Sommer
  • G Anker
  • E Wist
  • S Lundgren
  • J Bergh
  • G Kvalheim
Poster Presentation
  • 1.4k Downloads

Keywords

Breast Cancer Patient Epirubicin Independent Predictive Factor Stem Cell Support Bone Marrow Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

The present study aimed to investigate the clinical relevance of minimal residual cancer in breast cancer patients before and after high-dose adjuvant chemotherapy with or without progenitor stem cell support.

Methods

One hundred and eighteen high-risk stage II breast cancer patients entering the Scandinavian Study Group multicentre trial [1] were randomised to nine cycles of dose-escalated FEC (5-flurouracil, epirubicin, cyclophosphamide) or three cycles of standard FEC followed by high-dose chemotherapy. Bone marrow (BM) samples at diagnosis and 6 months after completion of chemotherapy were assessed for the presence of cytokeratin-positive (CK+) cells. CK+ cells in BM were evaluated as a prognostic and predictive marker and were compared with other defined prognostic factors of the primary tumour.

Results

Monitoring BM changes at time of diagnosis and at 6 months post-treatment is an independent predictive factor for breast cancer-specific survival (P = 0.001, univariate analysis). Those who have consistent CK-negative BM findings constitute a group of patients with good prognosis.

Conclusion

Monitoring of CK+ cells in BM before and after high-dose chemotherapy with or without stem cell support can be used clinically as a surrogate maker to predict outcome in breast cancer patients.

References

  1. 1.
    Bergh J, Wiklund T, Erikstein B, Lidbrink E, Lindman H, Malmstrom P, Kellokumpu-Lehtinen P, Bengtsson NO, Soderlund G, Anker G, et al: Tailored fluorouracil, epirubicin, and cyclophos-phamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer: a randomised trial. Scandinavian Breast Group 9401 study. Lancet. 2000, 356: 1384-1391. 10.1016/S0140-6736(00)02841-5.CrossRefPubMedGoogle Scholar

Copyright information

© BioMed Central 2005

Authors and Affiliations

  • V Drageset
  • JM Nesland
    • 2
  • B Erikstein
    • 1
  • E Skovlund
    • 1
  • H Sommer
    • 3
  • G Anker
    • 4
  • E Wist
    • 3
  • S Lundgren
    • 5
  • J Bergh
    • 6
  • G Kvalheim
    • 1
  1. 1.Laboratory for Cellular Therapy, Department of Medical Oncology and RadiotherapyThe Norwegian Radium Hospital, University of OsloNorway
  2. 2.Department of PathologyThe Norwegian Radium HospitalOsloNorway
  3. 3.Department of Medical Oncology and RadiotherapyUllevål University HospitalOsloNorway
  4. 4.Department of Medical Oncology and RadiotherapyHaukeland HospitalBergenNorway
  5. 5.Department of Oncology, St Olavs HospitalTrondheim University Hospital,TrondheimNorway
  6. 6.Radiumhemmet, Karolinska InstituteStockholmSweden

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