Arthritis Research & Therapy

, 3:P113 | Cite as

Nucleosome binding by serum amyloid P component from SLE patients

  • NHH Heegaard
  • L Rahbek
  • C Recke
Meeting abstract
  • 575 Downloads

Keywords

Public Health Future Study Apoptotic Cell Nephritis Normal Donor 

There is evidence in favor of apoptosis dysfunction being involved in the pathogenesis of SLE. Since mice deficient in the nucleosome-binding protein: serum amyloid P component (SAP) develop antinuclear immunity and nephritis it is possible that impaired clearance of nuclear material from apoptotic cells is the key defect. We therefore developed a solid-phase assay for the binding of SAP to nucleosomes and investigated the nucleosome binding characteristics of SAP from 20 different SLE patients as compared with normal donors. We could not demonstrate any significant differences between the groups and therefore the functions of other pentraxins (such as C-reactive protein) or DNA binding molecules (such as C1q) will be examined in future studies.

Copyright information

© BioMed Central Ltd 2001

Authors and Affiliations

  • NHH Heegaard
    • 1
  • L Rahbek
    • 1
  • C Recke
    • 1
  1. 1.Department of AutoimmunologyStatens Serum InstitutCopenhagenDenmark

Personalised recommendations