Influence of Amperozide on Disease Occurrence in a Pig Fattening Unit


The social and physical environments of animals and man have long been implicated in the etiology of infectious diseases. However, controlled experiments on adverse social and environmental stimuli and animal health are meagre (Kelley 1980). Recently the term psychoimmunology was coined to reflect the growing interest in the relationship between stress, reduced immune function and illness. For more than a decade it has been known that prolonged secretion of stress hormones, particularly corticosteroids, contributes to regression of the lymphoid tissues (Selye 1974, Freeman 1975). Now it has been shown more specifically, that the level of secretory immunoglobulin A is reduced in periods of high stress and that the activity of lymphocytes and natural killer cells are significantly reduced after intense stress periods (Wood 1985). Although the relationship between stress and immunity thus seems to be clear, studies linking those to disease are still a rarity.

This is a preview of subscription content, access via your institution.


  1. Barnett, S. A.: Physiological effects of “social stress” in wild rats - 1 The adrenal cortex. J. Psychosom. Res. 1958, 3, 1–11.

    CAS  Article  Google Scholar 

  2. Brain, P. F. & N. W. Nowell: Isolation versus grouping effects on adrenal and gonadal function in albino mice. 1 The male. Gen. Comp. Endocrinol. 1971, 16, 149–154.

    CAS  Article  Google Scholar 

  3. Bronson, F. H. & B. E. Eleftheriou: Adrenal response to fighting in mice: Separation of physical and psychological causes. Science 1965, U7, 627–628.

    Article  Google Scholar 

  4. Christensson, E.: Selective presynaptic and limbic effects on DA neurotransmission with a new psychotrophic drug, amperozide. Manuscript in preparation.

  5. Dantzer, R. & P. Mormede: Stress in farm animals: A need for re- evaluation. J. Anim. Sci. 1983, 57, 6–18.

    CAS  Article  Google Scholar 

  6. Freeman, B. M.: Physiological basis of stress. Proc. Roy. Soc. Med. 1975, 68, 427–437.

    CAS  Article  Google Scholar 

  7. Graves, H. B., K. L. Graves & G. W. Sheritt: Social behaviour and growth of pigs following mixing during the growing-finishing period. Appl. Anim. Ethol. 1978, 4, 169–180.

    Article  Google Scholar 

  8. Kelley, K. W.: Stress and immune function: A bibliographic review. Ann. Rech. Vet. 1980, 11, 445–478.

    CAS  PubMed  Google Scholar 

  9. McBride, G., J. W. James & N. Hodgens: Social behaviour of domestic animals. Anim. Prod. 1964, 6, 129–139.

    Google Scholar 

  10. Meese, G. B. & R. Ewbank: The establishment and nature of the dominance hierarchy in the domesticated pig. Anim. Behav. 1973, 21, 326–334.

    Article  Google Scholar 

  11. Olsson, N.-G., G. Andersson, A. Bjork, E. Christensson, K. Martinsson & J. Rabe: Medicinsk behandling av “pellesyndromet” hos gris (Medical treatment of wasting pigs). Svensk vet. tidn. 1984, 36, 601–605.

    Google Scholar 

  12. Selye, H.: Stress without Distress. Edited by Hodder & Stoughton, London 1974.

    Google Scholar 

  13. Wood, C.: How stress may predispose to disease. New Scientist 1985, 106, (1463), 31.

    Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Stefan Fabiansson.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fabiansson, S., Rabe, J. & Olsson, NG. Influence of Amperozide on Disease Occurrence in a Pig Fattening Unit. Acta Vet Scand 27, 141–144 (1986).

Download citation