The action of aminoguanidine on the liver of trained diabetic rats



This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.


The rats used in this study were divided into five groups: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.


The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.


Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin.

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Corresponding author

Correspondence to Maria Izabel Camargo-Mathias.

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The authors had no conflict of interest.

Authors’ contributions

ETMN conceived of the study, wrote draft the manuscript. PRO conceived of the study, and participated in its design and coordination. LPS wrote draft the manuscript. FDC-P wrote draft the manuscript. MAD and AZ conceived of the study. MIC-M conceived of the study, participated in its design and coordination and revised the manuscript. All authors read and approved the final manuscript.

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e Nico, E.T.M., de Oliveira, P.R., de Souza, L.P. et al. The action of aminoguanidine on the liver of trained diabetic rats. J Diabetes Metab Disord 12, 40 (2013).

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  • Aminoguanidine
  • Diabetes type 1
  • Rats
  • Liver
  • Physical exercises