Correlation of serum homocysteine and previous history of gestational diabetes mellitus



Gestational diabetes mellitus (GDM) is a common pregnancy condition. In this study, the risk of having a history of previous GDM (pGDM) on serum homocysteine level was assessed


Biomedical parameters, serum homocysteine, Insulin, homeostatic model assessment (HOMA) in women with (n = 52) and without pGDM (n = 51) were assessed. According to their current status of Oral Glucose Tolerance Test (GTT), the participants in each group were divided into two subgroups of normal or impaired GTT.


Mean serum homocysteine in normal women was 8.56 ± 3.19 vs 11.44 ± 7.34 μmol/L (p < 0.01) in women with pGDM. Two groups had significant differences in respect to serum insulin levels (8.35 ± 5.12 vs 12.48 ± 5.44, p < 0.002), and HOMA-IR (1.90 ± 1.30 vs 2.91 ± 1.30, p < 0.002). In women without pGDM, serum homocysteine in normal and impaired GTT were 7.60 ± 1.69 and 10.52 ± 3.65 μmol/L (p = 0.03), respectively, while in women with pGDM, the figures were 8.38 ± 2.52 and 14.00 ± 10.17 (p < 0.01), respectively. In multi regression analysis an association between history of GDM and homocysteine levels was presented (OR: 7.71, 95% CI: 1.67-35.42, p < 0.001).


A trend of elevation of homocysteine is presented in women with pGDM, that is more prominent in women with impaired GTT, and shows a significant correlation with history of GDM. Further studies with larger sample size are suggested.

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Gestational diabetes mellitus


Fasting blood sugar


Glucose tolerance test


Normal glucose tolerance test


Impaired glucose tolerance test




High density lipoprotein


Low density lipoprotein


Homoeostasis model assessment.


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Correspondence to Hossein Fakhrzadeh.

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Competing interest

The authors report no conflict of interest.

Authors’ contributions

SA: Drafted the manuscript. HF: designed the study, intellectually revised the manuscript. FSh: designed the study, performed the analysis. MM: participated in study design. ZB: collected the data. MGH: participated in study design. AH: participated in study design. BL: approved the final version. All authors read and approved the final manuscript.

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Alatab, S., Fakhrzadeh, H., Sharifi, F. et al. Correlation of serum homocysteine and previous history of gestational diabetes mellitus. J Diabetes Metab Disord 12, 34 (2013).

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  • Gestational diabetes mellitus
  • Homocysteine
  • Diabetes mellitus