EJNMMI Physics

, 1:A69 | Cite as

Quantification and accuracy of clinical [11C]-PiB PET/MRI: the effect of MR-based attenuation correction

  • Ian Law
  • Flemming L Andersen
  • Adam E Hansen
  • Steen G Hasselbalch
  • Claes Ladefoged
  • Sune H Keller
  • Søren Holm
  • Liselotte Højgaard
Open Access
Meeting abstract

Keywords

Mild Cognitive Impairment Attenuation Correction Visual Evaluation Grey Matter Region Amyloid Imaging 

The Dixon-Water-Fat segmentation (DWFS) method is a standard attenuation correction (AC) method in PET/MRI on the Siemens mMR and has demonstrated a systematic quantitative bias in [18F]-FDG-PET/MRI studies of the brain compared to PET/CT. The aim of this study was to evaluate the impact of DWFS-AC in a hybrid PET/MR scanner on regional and global quantitation of [11C]-PiB cerebral amyloid imaging of the brain and in the clinical reading.

Twenty-eight healthy volunteers, 6 with mild cognitive impairment (MCI), 4 with Alzheimers disease (AD), and 6 other dementia cases underwent a simultaneous PET/MRI (Siemens mMR) acquisition 40 min pi of (170-709) MBq [11C]-PiB. A single 30 min frame was reconstructed twice (OSEM-3D, 21it 4 sub, 5 mm Gauss) with the only difference being the AC calculation. AC was performed using either the standard DWFS or a head low-dose CT scan acquired independently on the same day. Activity concentration (Bq/mL) was sampled on AC-PET from symmetrically delineated ROI’s. Ratios of region-to-cerebellar grey matter (SUVr) were calculated. Amyloid uptake was considered abnormal at cortical SUVr >1.5 or increased amyloid uptake in two or more grey matter regions on visual evaluation.

The average activity concentration in all ROI’s was biased by -18 % in DWFS-AC compared to CT-AC. Although the visual categorization of both, amyloid-positive (n=11) and -negative (n=33) scans was unaffected by DWFS-AC, 3 healthy subjects were quantitatively reclassified as amyloid positive. The SUVr values were overestimated by 0.11 in the caudate nuclei and 0.04 in lateral cortical ROI’s in DWFS-AC compared to CT-AC.

The visual and quantitative consequences of MR-AC using DWFS in the brain with [11C]-PiB exhibit a noticeable radially variable bias. Although robust in visual evaluation, the quantitative diagnostic criteria (SUVr) using this biomarker with DWFS-AC may need to be modified.

Copyright information

© Law et al; licensee Springer 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Ian Law
    • 1
  • Flemming L Andersen
    • 1
  • Adam E Hansen
    • 1
  • Steen G Hasselbalch
    • 2
  • Claes Ladefoged
    • 1
  • Sune H Keller
    • 1
  • Søren Holm
    • 1
  • Liselotte Højgaard
    • 1
  1. 1.The Department of Clinical PhysiologyNuclear Medicine and PET, RigshospitaletDenmark
  2. 2.Memory Disorders Research Group, RigshospitaletDenmark

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