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Immune profiling in human breast cancer is predictive of 5- and 10-year survival.

  • Brendon Coventry
  • Michael J Weightman
  • John Bradley
  • John M Skinner
Open Access
Poster presentation

Keywords

Breast Cancer Breast Cancer Patient Breast Carcinoma Human Breast Cancer Receptor Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

Immunotherapy for breast cancer is now being seriously considered, despite past beliefs that this cancer type was non-immunogenic. Immune profiling has been variably associated with outcome, but standard techniques have greatly limited interpretation. These studies examine immune profiling of breast cancer patients using high-sensitivity methods in relation to clinical outcome.

Methods

High-sensitivity detection and analysis methods were used to determine Immune Profiles of female human breast cancer in Tumour Infiltrating Leukocytes (TIL) in longitudinal cohort comparative outcome studies.

Results

Immune profiles showed predominantly CD3, CD4, CD45RO TIL with low/absent IL-2a receptor expression. However, these were significantly correlated to 5- and 10-year survival times.

Conclusions

Immune profiling of the TIL infiltrate in human breast carcinoma using high-sensitivity detection and analysis techniques showed predominance of CD3 cells, being ab-TCR, CD4 T cells of mainly memory phenotype. Importantly, these findings were strongly predictive of 5- and 10-year survival. This indicates the real possibility that TIL infiltration in breast cancer might be open to immunological manipulation therapeutically to improve clinical outcome.

Copyright information

© Coventry et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Brendon Coventry
    • 1
  • Michael J Weightman
    • 1
  • John Bradley
    • 2
  • John M Skinner
    • 3
  1. 1.Discipline of SurgeryUniversity of Adelaide & Breast, Endocrine & Surgical Oncology Unit, Royal Adelaide HospitalAustralia
  2. 2.Department of Clinical ImmunologyFlinders University, Flinders Medical CentreAdelaideAustralia
  3. 3.PathologyFlinders University, Flinders Medical CentreAdelaideAustralia

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