Relationship between temperature and T2 in subcutaneous fat and bone marrow at 3T
- 271 Downloads
KeywordsUterine Fibroid Focus Ultrasound Fiber Optic Sensor Painful Bone Metastasis Resonant Frequency Shift
MR-guided high-intensity focused ultrasound (HIFU) for treatment of uterine fibroids and painful bone metastases uses the proton resonant frequency shift (PRF) for temperature monitoring in water-based tissues. However, PRF fails to detect temperature changes in tissues with high lipid content, such as fat and bone marrow. Previous studies have shown a change in T2 of subcutaneous fat, red and yellow bone marrow during treatments with focused ultrasound. The lack of calibration data for 3T acquisitions, however, makes it difficult to convert T2 values into maps of tissue temperature.
In this study we investigated the dependence of T2 temperature on temperature in porcine adipose tissue and bovine yellow bone marrow at thermal equilibrium at 3T.
Results and conclusions
Relationship between T2 and temperature (ms/°C) for porcine adipose tissue (fat) and bovine yellow bone marrow (marrow).
Water Suppr. TE = 30/150
Water Suppr. TE = 38/182
No Water Suppr. TE = 38/182
This work was supported by NIH Grants R00HL097030, and research support by GE and InSightec.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.