P324: Management of risk in a country in crisis: hepatonephritis cases related to artemisinin- based combinations therapy
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KeywordsHepatitis Retrospective Study Health Professional Risk Management Drug Reaction
To analyze risk management when occurred hepatonephritis cases related to Artemisinin-based Combinations Therapy.
A technical committee of management of hepatonephritis cases has been set up by the health ministry. The terms of references were: 1) state of knowledges on the subject from the pharmacovigilance database of Côte-d’Ivoire; 2) Carrying out of an investigation in public and private hospitals; 3) start -up a plan of communication for the health professionals and population.
Results: States of knowledges: for 10 years, serious Adverse Drug reactions have been notified (57%), like black fever, hepatonephritis and serious hepatitis cases related to any antimalarial monotherapies : amodiaquin, artemisinin derivatives and quinine. Retrospective study: we collected 100 files. The principal damage was hepatic (63%), hepatorenal (26 %) and hematologic (19%). Antimalarial drugs implicated were: quinine (30,4%), artemether-lumefantine (21,4%) and artesunate-sulfamethopyrazine (13,6%)..Prospective study: We have analyzed 25 cases over 3 months of investigation.
Conclusion: Start-up of a plan of communication: we drafted and sent an alarm note and recommendations of good use of antimarial combinotherapies to prescribers and dispensers.
Disclosure of interest
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