Advertisement

Association between inflammatory extension and the ventricular size in adult chronic communicating hydrocephalus: An experimental model of adult hydrocephalus

  • Ignacio Jusue-Torres
  • Jennifer Lu
  • Eric W Sankey
  • Tito Vivas-Buitrago
  • Joshua Crawford
  • Mikhail Pletnikov
  • Jiadi Xu
  • Ari Blitz
  • Barbara Crain
  • Alicia Hulbert
  • Hugo Guerrero-Cazares
  • Oscar Gonzalez-Perez
  • Alfredo Quiñones-Hinojosa
  • Pat McAllister
  • Daniele Rigamonti
Open Access
Oral presentation
  • 439 Downloads

Keywords

Hydrocephalus Kaolin Subarachnoidal Space Superior Sagittal Sinus Ventricular Enlargement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

The pathogenesis of normal pressure hydrocephalus (NPH) is not fully understood and the relationship between inflammatory reaction extension and the ventricular enlargement is unknown.

Methods

Bilateral subarachnoidal injection of kaolin was administered in the cranial convexities of 20 adult rats. MRI was obtained using a Bruker Biospec 11.7 T MRI scanner at 14, 60, 90 and 120 days post kaolin injection. Radiological kaolin extension was defined by the number of kaolin locations showed in the MRI studies. At the end of the experiment, the heads of the rats were decalcified and sliced along with the skull in order to preserve the meninges and bone. A blinded neuropathologist studied the anatomical preparations and analyzed kaolin extension and the inflammatory and fibrotic response.

Results

Radiological ventricular size showed progressive growth over time at all times (p<0.0001). The fastest ventricular enlargement happened within the first 2 months. Pathological specimens revealed kaolin location at the subarachnoidal space. The extension of the kaolin migration was heterogeneous among rats. Inflammatory and fibrotic response was present at the cranial convexities in all rats, adjacent to superior sagittal sinus in 94% rats, at the interhemispheric fissure in 56% rats, at the Olfactory Bulb in 61% rats, at the anterior basal cisterns in 72% rats, supracerebellar in 56% rats, at the quadrigeminal cisterns in 61% rats, at the lateral midbrain cisterns in 50% rats and within the Virchow-Robin spaces in 61% rats. The extension of the inflammatory response in the subarachnoidal space was associated with ventricular size (p=0.02), and the rate of ventricular enlargement (p=0.03).

Conclusions

The extension of the inflammatory response to kaolin injected in the subarachnoidal space is associated with ventricular size and the rate of ventricular enlargement in adult rats.

References

  1. 1.
    Sankey EW, Jusue-Torres I, Elder BD, et al: Functional gait outcomes for idiopathic normal pressure hydrocephalus after primary endoscopic third ventriculostomy. J Clin Neurosci. 2015, 1-6.Google Scholar
  2. 2.
    Moran D, Kosztowski TA, Jusue-Torres I, et al: Does CT wand guidance improve shunt placement in patients with hydrocephalus?. Clin Neurol Neurosurg. 2015, 132: 26-30.CrossRefPubMedGoogle Scholar
  3. 3.
    Jusue Torres I, Hoffberger JB, Rigamonti D: Complications Specific to Lumboperitoneal Shunt. Complications of CSF Shunting in Hydrocephalus. 2015, Springer, 203-11.Google Scholar
  4. 4.
    Elder BD, Sankey EW, Goodwin CR, Jusue-Torres I, Khattab MH, Rigamonti D: Outcomes and Experience with Lumbopleural Shunts in the Management of Idiopathic Intracranial Hypertension. World Neurosurg. 2015, 1-6.Google Scholar
  5. 5.
    Jusué-Torres I, Hoffberger JB, Rigamonti D: Complications of Lumboperitoneal Shunts for Idiopathic Intracranial Hypertension. Cureus. 2014Google Scholar
  6. 6.
    Jusue Torres I, Hoffberger JB, Rigamonti D: Complications of Lumboperitoneal Shunts for Normal Pressure Hydrocephalus. Cureus. 2014Google Scholar
  7. 7.
    Elder BD, Bankah P, Blitz AM, et al: Core imaging in adult hydrocephalus. Edited by: Rigamonti D. 2014, Adult Hydrocephalus: Cambridge University Press, 110-20.CrossRefGoogle Scholar

Copyright information

© Jusue-Torres et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Ignacio Jusue-Torres
    • 1
  • Jennifer Lu
    • 1
  • Eric W Sankey
    • 1
  • Tito Vivas-Buitrago
    • 1
  • Joshua Crawford
    • 2
  • Mikhail Pletnikov
    • 2
  • Jiadi Xu
    • 3
  • Ari Blitz
    • 4
  • Barbara Crain
    • 5
  • Alicia Hulbert
    • 6
  • Hugo Guerrero-Cazares
    • 1
  • Oscar Gonzalez-Perez
    • 7
  • Alfredo Quiñones-Hinojosa
    • 1
  • Pat McAllister
    • 8
  • Daniele Rigamonti
    • 1
  1. 1.Department of NeurosurgeryJohns Hopkins University. School of MedicineUSA
  2. 2.Department of Psychiatry and Behavioral SciencesJohns Hopkins University, School of MedicineUSA
  3. 3.Johns Hopkins UniversitySchool of Medicine, F. M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger InstituteUSA
  4. 4.Department of Radiology and Radiological ScienceJohns Hopkins University, School of MedicineUSA
  5. 5.Department of Pathology, Division of NeuropathologyJohns Hopkins University, School of MedicineUSA
  6. 6.Department of OncologyJohns Hopkins University, School of MedicineUSA
  7. 7.Facultad de Psicologia, Laboratory of NeuroscienceUniversity of ColimaMexico
  8. 8.Department of NeurosurgeryWashington University, School of Medicine in St LouisUSA

Personalised recommendations