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Clinical relevance of IgE-antibodies to PR-10 proteins in patients with syndrome of oral allergy

  • E Bass
  • M Mokronosova
Open Access
Poster presentation
  • 659 Downloads

Keywords

Immune Response Clinical Manifestation Clinical Relevance Plant Food Food Allergen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

A considerable number of pollen-allergic patients develops allergy to plant foods, which has been attributed to cross-reactivity between food and pollen allergens belongs to PR-10 proteins. The majority of these patients refuse from take the foods containing PR-10 explaining bad taste or sense of itch in the mouth - syndrome of oral allergy (SOA). It is assumed that the primary is sensitization to pollen origin PR-10 proteins and induction of the IgE-aB to the fruit & vegetable origin PR-10 is secondary. The aim of the study: to measure the IgE-aB to PR-10 proteins in patients with SOA.

Methods

There were 21 patients (pts) with SOA (12 male/9 female, age 1 – 42 years) were observed. From them 18 was suffered from pollen allergy. Component-resolved diagnosis was provided by ImmunoCap ISAC (ThermoFisher Scientific, Sweden) with all 21 sera of observed pts.

Results

18/21 of pts had positive levels of specific IgE-aB to pollen PR-10 allergens (rAln g 1, rBet v 1 and rCor a 1.0101). The levels of specific IgE-aB to rBet v 1 were positive in 17/21 pts (81%); to rAln g 1 in 12/21 (57,1%); to rCor a 1.0101 in 8/21 (38,1%). There were 17/21 pts who had specific IgE-aB both to pollen and to the food allergens. The levels of specific IgE-aB to the apple (rMal d 1) were positive in 17/21 cases (81%); to peach (rPru p 1) and peanut (rAra h 8) in 13/21 (69%); to hazelnut (rCor a 1.0401) and soybeans (rGly m 4) in 11/21 (52,4%); to the carrot (rDau c 1) and celery (rApi g 1) in 3/21 (14,3%) cases; to rAct d 8 (kiwi) were positive 2/21 (9,5%) of pts. The SOA to such fruits as apple, peach and hazelnut is often in pts with SOA. Clinical manifestation of allergy to peanut and soybeans are rarer. There were IgE-aB only to the plant food PR-10 proteins but not to the pollen in 3/21 samples of sera (14, 3%). One of these pts had specific IgE-aB only to rMal d 1 (apple), one – to rAra h 8 (peanut), and one was sensitized to the apple, hazelnut and soybeans.

Conclusion

The sensitization to PR-10 protein is followed by primary immune response to tree’s pollen, predominantly rBet v 1. But in some cases the primary sensitization to PR-10 was realized to plant foods. The SOA develops in sensitized patients after eating nuts, fruits and vegetables (except peanuts and soybeans) containing PR-10 proteins.

Disclosure of interest

None declared.

Copyright information

© Bass and Mokronosova; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • E Bass
    • 1
  • M Mokronosova
    • 1
  1. 1.Mechnikov’s Research Institute for Vaccines and SeraMoscowRussian Federation

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