How early to start: what do observational data suggest?
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KeywordsPublic Health Infectious Disease Cohort Study Early Treatment Observational Data
National and international guidelines on antiretroviral therapy for HIV infection recently changed to recommend earlier treatment, following the publication during 2009 of two collaborative analyses of HIV cohort studies [1, 2]. These studies used different methodologies, and reached different conclusions about the benefits of very early treatment. I will describe their methods, and possible reasons for differences in their results.
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